TY - JOUR
TI - B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease
AU - Kolovou, K.
AU - Laskari, K.
AU - Roumelioti, M.
AU - Tektonidou, M.G.
AU - Panayiotidis, P.
AU - Boletis, J.N.
AU - Marinaki, S.
AU - Sfikakis, P.P.
JO - Clinical Immunology Newsletter
PY - 2020
VL - 217
TODO - null
SP - null
PB - Academic Press Inc.
SN - 0197-1859
TODO - 10.1016/j.clim.2020.108488
TODO - creatinine;  cyclophosphamide;  mycophenolate mofetil;  rituximab;  immunoglobulin heavy chain, adolescent;  adult;  aged;  Article;  B lymphocyte;  blood sampling;  chronic kidney failure;  controlled study;  creatinine blood level;  disease duration;  female;  focal glomerulosclerosis;  glomerulonephritis;  glomerulopathy;  glomerulosclerosis;  human;  humoral immune deficiency;  idiopathic disease;  immunoglobulin A nephropathy;  kidney biopsy;  kidney tissue;  lupus erythematosus nephritis;  major clinical study;  male;  membranoproliferative glomerulonephritis;  membranous glomerulonephritis;  multivariate analysis;  podocyte;  priority journal;  systemic lupus erythematosus;  tissue expansion;  urine sampling;  B lymphocyte;  focal glomerulosclerosis;  hematuria;  immunoglobulin A nephropathy;  immunology;  kidney tumor;  lupus erythematosus nephritis;  membranous glomerulonephritis;  middle aged;  pathology;  proteinuria;  very elderly, Aged;  Aged, 80 and over;  B-Lymphocytes;  Female;  Glomerulonephritis, IGA;  Glomerulonephritis, Membranous;  Glomerulosclerosis, Focal Segmental;  Hematuria;  Humans;  Immunoglobulin Heavy Chains;  Kidney Neoplasms;  Lupus Nephritis;  Male;  Middle Aged;  Podocytes;  Proteinuria
TODO - B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idiopathic membranoproliferative glomerulonephritis, 0/4 pauci-immune vasculitis) and 17% of control patients with renal cancer. In multivariate analysis, oligoclonal B-cells were associated with podocyte injury and the grade of glomerulosclerosis (both p = .009). B-cell oligoclonal expansions were not found in the paired peripheral blood samples. We postulate that B-cell expansion in the kidney results from local stimuli, including antigens expressed on podocytes. Further studies to unravel the role of oligoclonal B-cells in (auto)immune-mediated kidney disease are warranted. © 2020 Elsevier Inc.
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