TY - JOUR
TI - The complex crosstalk between inflammatory cytokines and ventricular arrhythmias
AU - Kouvas, N.
AU - Kontogiannis, C.
AU - Georgiopoulos, G.
AU - Spartalis, M.
AU - Tsilimigras, D.I.
AU - Spartalis, E.
AU - Kapelouzou, A.
AU - Kosmopoulos, M.
AU - Chatzidou, S.
JO - Cytokine
PY - 2018
VL - 111
TODO - null
SP - 171-177
PB - INSTAP Academic Press
SN - 1043-4666, 1096-0023
TODO - 10.1016/j.cyto.2018.08.007
TODO - connexin 43;  cytokine;  interleukin 1;  interleukin 6;  ion channel;  reactive oxygen metabolite;  tumor necrosis factor;  biological marker;  cytokine, autonomic nervous system;  cardiac resynchronization therapy;  heart electrophysiology;  heart muscle ischemia;  heart right ventricle dysplasia;  heart ventricle arrhythmia;  heart ventricle fibrillation;  heart ventricle tachycardia;  human;  myocardial ischemia reperfusion injury;  nonhuman;  pathophysiology;  prediction;  prevalence;  priority journal;  protein blood level;  protein function;  protein interaction;  QT prolongation;  Review;  sudden cardiac death;  systemic inflammatory response syndrome;  therapy effect;  action potential;  animal;  autoimmune disease;  cardiovascular system;  heart arrhythmia;  inflammation;  metabolism;  physiology, Action Potentials;  Animals;  Arrhythmias, Cardiac;  Autoimmune Diseases;  Biomarkers;  Cardiovascular System;  Cytokines;  Humans;  Inflammation
TODO - The network of cytokines consists one of the most extensively studied signaling systems of human body. Cytokines appear to modulate pathogenesis and progress of many different diseases in the human body, particularly in regards to cardiovascular system. However, their effects on the electrical system of the heart has been neglected. Over the past decade, attemps to understand this relationship led to the uncovering of the direct and indirect effects of cytokines on action potential propagation and cell depolarization. This relationship has been depicted in clinical practice as serum levels of cytokines are increasingly associated with prevalence of ventricular arrhythmias either isolated or secondary to either a heart condition or a systemic auto-immune disease. Thus, they present an appealing potential as a biomarker for prediction of arrhythmia generation, as well as the ourtcome of electrophysiological interventions. © 2018 Elsevier Ltd
ER -