TY - JOUR
TI - Oropharyngeal and laryngeal but not oral cancers are strongly associated with high-risk human papillomavirus in 172 Greek patients
AU - Tsimplaki, E.
AU - Argyri, E.
AU - Sakellaridis, A.
AU - Kyrodimos, E.
AU - Xesfyngi, D.
AU - Panotopoulou, E.
JO - Journal of Medical Virology
PY - 2017
VL - 89
TODO - 1
SP - 170-176
PB - John Wiley and Sons Inc
SN - 0146-6615, 1096-9071
TODO - 10.1002/jmv.24614
TODO - virus DNA;  virus DNA, adult;  Article;  controlled study;  cytology;  disease association;  DNA determination;  female;  genotype;  Greek (people);  head and neck squamous cell carcinoma;  high risk patient;  human;  human tissue;  infection risk;  larynx cancer;  major clinical study;  male;  microarray analysis;  mouth cancer;  oropharynx cancer;  papillomavirus infection;  tumor biopsy;  tumor differentiation;  tumor localization;  virus detection;  adolescent;  aged;  Carcinoma, Squamous Cell;  case control study;  classification;  complication;  genetics;  Greece;  isolation and purification;  Laryngeal Neoplasms;  middle aged;  Mouth Neoplasms;  Oropharyngeal Neoplasms;  Papillomaviridae;  papillomavirus infection;  risk assessment;  very elderly;  virology;  young adult, Adolescent;  Adult;  Aged;  Aged, 80 and over;  Carcinoma, Squamous Cell;  Case-Control Studies;  DNA, Viral;  Female;  Genotype;  Greece;  Humans;  Laryngeal Neoplasms;  Male;  Middle Aged;  Mouth Neoplasms;  Oropharyngeal Neoplasms;  Papillomaviridae;  Papillomavirus Infections;  Risk Assessment;  Young Adult
TODO - A strong and consistent association has been reported between human papillomavirus (HPV) infection and oropharyngeal cancer, whereas a similar link has not yet been clarified in oral and laryngeal cancer. The purpose of this study was to investigate the association between HPV infection and head and neck squamous cell carcinoma (HNSCC) in Greek patients. Cytological or tissue specimens from 172 cases patients with HNSCC and cytological specimens from 91 control subjects were analyzed for HPV DNA detection and genotyping using a microarray-based assay. Multivariate logistic regression was used to estimate odds ratios (ORs) for the association between the presence of HPV infection and HNSCC for each of the tumor site, after adjustment for potential confounders. The adjusted ORs for positivity to high-risk HPV infection for oropharyngeal and laryngeal cancer were 20.3 (95% CI: 1.7–250.1) and 22.8 (95% CI: 2.5–206.2), respectively. High-risk HPV infection was not significantly associated with oral cancer. HPV infection was independently associated with poorly differentiated tumors (OR = 2.8; 95% CI: 1.1–7.5). Our results suggest a strong association of high-risk HPV infection with oropharyngeal and laryngeal cancer. J. Med. Virol. 89:170–176, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
ER -