TY - JOUR
TI - Transplacental infection of coxsackievirus B3 pathological findings in the fetus
AU - Konstantinidou, A.
AU - Anninos, H.
AU - Spanakis, N.
AU - Kotsiakis, X.
AU - Syridou, G.
AU - Tsakris, A.
AU - Patsouris, E.
JO - Journal of Medical Virology
PY - 2007
VL - 79
TODO - 6
SP - 754-757
PB - 
SN - 0146-6615, 1096-9071
TODO - 10.1002/jmv.20887
TODO - adult;  akinesia;  arthrogryposis;  article;  autopsy;  blood vessel calcification;  controlled study;  Coxsackie virus B3;  echography;  female;  fetus;  gene sequence;  gestational age;  heart ventricle hypertrophy;  human;  interstitial pneumonia;  meningoencephalitis;  nucleotide sequence;  placental transfer;  virus infection, Abortion, Induced;  Adult;  Arthrogryposis;  Base Sequence;  Blood Vessels;  Calcinosis;  Cardiomegaly;  Chorionic Villi;  Coxsackievirus Infections;  Disease Transmission, Vertical;  Enterovirus B, Human;  Female;  Fetal Diseases;  Fetal Movement;  Fetus;  Histocytochemistry;  Humans;  Leukoencephalitis, Acute Hemorrhagic;  Lung Diseases, Interstitial;  Molecular Sequence Data;  Placenta Diseases;  Pregnancy;  Pregnancy Complications, Infectious;  Sequence Alignment;  Ultrasonography, Prenatal, Coxsackievirus;  Enterovirus
TODO - Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy. © 2007 Wiley-Liss, Inc.
ER -