TY - JOUR
TI - Altered immunophenotypic parameters in infertile women. Possible role of herpes viremia
AU - Thomas, D.
AU - Michou, V.
AU - Moustakarias, T.
AU - Aleporou, V.
AU - Matzavinos, T.
AU - Mitsakos-Barbagiannis, K.
AU - Kalofoutis, A.
AU - Tsilivakos, V.
JO - American Journal of Reproductive Immunology
PY - 2005
VL - 54
TODO - 2
SP - 101-111
PB - 
SN - 1046-7408, 1600-0897
TODO - 10.1111/j.1600-0897.2005.00293.x
TODO - CD16 antigen;  CD4 antigen;  CD56 antigen;  CD8 antigen, adult;  article;  cohort analysis;  controlled study;  correlation analysis;  Epstein Barr virus;  female;  female infertility;  herpes;  human;  immunological parameters;  immunophenotyping;  immunostimulation;  leukocyte count;  lymphocyte count;  major clinical study;  natural killer cell;  peripheral lymphocyte;  priority journal;  statistical analysis;  T lymphocyte;  T lymphocyte subpopulation;  viremia, Adult;  Antigens, CD;  CD4-CD8 Ratio;  Epstein-Barr Virus Infections;  Female;  Humans;  Infertility, Female;  Lymphocytes;  Viremia
TODO - Problem: Purpose of this study was to reveal any alteration in peripheral blood lymphocytic concentrations of a large cohort of infertile women and to investigate the possible role of herpes viremia in the peripheral immunostimulation. Method of study: The immunophenotypic characteristics and the presence of herpes viruses DNA in the peripheral blood of 168 infertile women were studied. Results: Peripheral CD56+/CD16+ natural killer (NK) cell concentration, CD56+/CD16- NK cell concentration, white blood cell (WBC) concentration and lymphocyte concentration were statistically correlated to herpes viremia. Epstein-Barr virus (EBV) viremia is related with a limited reduction of CD56+/CD16- cell levels in the peripheral blood of infertile women with regard to the rest of herpes viruses. High T-lymphocyte concentration, CD4+ T-cell concentration and CD8+ T-cell concentration was observed in women positive for three different kinds of herpes viruses (triple viremia) in the peripheral blood. Conclusions: Assuming that all women under study remained asymptomatic, these data suggest that subclinical herpesvirus viremia may be an important cause of peripheral immunostimulation in women with a history of infertility. © 2005 Blackwell Munksgaard.
ER -