TY - JOUR
TI - Blood eosinophils as predictor of outcomes in patients hospitalized for COPD exacerbations: a prospective observational study
AU - Kostikas, K.
AU - Papathanasiou, E.
AU - Papaioannou, A.I.
AU - Bartziokas, K.
AU - Papanikolaou, I.C.
AU - Antonakis, E.
AU - Makou, I.
AU - Hillas, G.
AU - Karampitsakos, Τ.
AU - Papaioannou, O.
AU - Dimakou, K.
AU - Apollonatou, V.
AU - Verykokou, G.
AU - Papiris, S.
AU - Bakakos, P.
AU - Loukides, S.
JO - Biomarker Insights
PY - 2021
VL - 26
TODO - 4
SP - 354-362
PB - Taylor and Francis Ltd.
SN - 1177-2719
TODO - 10.1080/1354750X.2021.1903998
TODO - antibiotic agent;  biological marker;  C reactive protein;  corticosteroid;  C reactive protein;  corticosteroid, aged;  Article;  blood;  chronic obstructive lung disease;  clinical decision making;  clinical evaluation;  controlled study;  disease exacerbation;  dyspnea;  eosinophil;  female;  follow up;  fraction of inspired oxygen;  Horowitz index;  hospital admission;  hospital discharge;  hospital patient;  human;  major clinical study;  male;  mortality;  multicenter study;  observational study;  outcome assessment;  post hoc analysis;  predictive value;  prospective study;  blood;  chronic obstructive lung disease;  clinical trial;  disease exacerbation;  eosinophil;  hospitalization;  Kaplan Meier method;  length of stay;  leukocyte count;  metabolism;  middle aged;  prognosis;  prospective study, Adrenal Cortex Hormones;  Aged;  C-Reactive Protein;  Disease Progression;  Eosinophils;  Female;  Hospitalization;  Humans;  Kaplan-Meier Estimate;  Length of Stay;  Leukocyte Count;  Male;  Middle Aged;  Outcome Assessment, Health Care;  Prognosis;  Prospective Studies;  Pulmonary Disease, Chronic Obstructive
TODO - Purpose: In the present prospective multicentre observational study, we evaluated the potential role of blood eosinophils on the outcomes of patients hospitalized for COPD exacerbations. Material and methods: Consecutive patients >40 years with a previous COPD diagnosis were recruited. Blood eosinophils were measured on admission prior to the initiation of treatment and were evaluated in three groups (<50, 50–149 and ≥150 cells/μL). Patients received standard care and were followed up for a year. Results: A total of 388 patients were included (83.5% male, mean age 72 years). Patients with higher blood eosinophils had less dyspnoea (Borg scale), lower C-reactive protein (CRP) and higher PaO2/FiO2 (partial pressure for oxygen/fraction of inhaled oxygen), and were discharged earlier (median 11 vs. 9 vs. 5 days for patients with <50, 50–149 and ≥150 cells/μL, respectively). Patients with <50 cells/μL presented higher 30-day and 1-year mortality, whereas there were no differences in moderate/severe COPD exacerbations between the three groups. In a post hoc analysis, treatment with inhaled corticosteroids as per physicians’ decision was associated with better exacerbation prevention during follow-up in patients with ≥150 cells/μL. Conclusions: Higher blood eosinophils were associated with better outcomes in hospitalized COPD patients, further supporting their use as a prognostic biomarker. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
ER -