TY - JOUR
TI - Association of various risk factors with chronic lymphocytic leukemia and its cytogenetic characteristics
AU - Karakosta, M.
AU - Delicha, E.-M.
AU - Kouraklis, G.
AU - Manola, K.N.
JO - Archives of Environmental and Occupational Health
PY - 2016
VL - 71
TODO - 6
SP - 317-329
PB - Taylor and Francis Inc.
SN - 1933-8244
TODO - 10.1080/19338244.2015.1116429
TODO - detergent;  environmental chemical;  fertilizer;  metal;  pesticide;  petroleum;  rubber, adult;  aged;  Article;  bone marrow cell;  chromosome 11q;  chromosome 13q;  chromosome aberration;  chromosome analysis;  chromosome deletion;  chronic lymphatic leukemia;  controlled study;  cytogenetics;  environmental exposure;  family history;  female;  heredity;  human;  lifestyle;  major clinical study;  male;  medical history;  neoplasm;  occupational exposure;  pathogenesis;  pneumonia;  priority journal;  questionnaire;  radiation exposure;  risk factor;  smoking;  case control study;  genetics;  Greece;  Leukemia, Lymphocytic, Chronic, B-Cell;  middle aged;  risk factor, Aged;  Case-Control Studies;  Chromosome Aberrations;  Cytogenetic Analysis;  Female;  Greece;  Humans;  Leukemia, Lymphocytic, Chronic, B-Cell;  Male;  Middle Aged;  Risk Factors
TODO - This study aimed to investigate whether occupational and environmental exposures, lifestyle, family, and medical history are associated with chronic lymphocytic leukemia (CLL) risk and its chromosomal abnormalities. The study included 138 CLL cases and 141 age- and sex-matched controls. Information data were collected through in-person interviews from cases and controls. Cytogenetic analysis was performed on CLL bone marrow cells. Positive associations were found between CLL and cancer family history, smoking, pneumonia, and exposure to petroleum, metals, pesticides/chemical fertilizers, detergents, and medical radiation. Chromosome deletions of 11q and 13q were more frequent in patients exposed to pesticides and rubber, respectively. This study investigated for the first time specific risk factors in relation to CLL aberrations and presented positive correlations. Moreover, it indicates the possible involvement of specific occupational and lifestyle risk factors in the onset of CLL. © 2016 Taylor & Francis.
ER -