TY - JOUR
TI - Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries
AU - Patrani, M.
AU - Tsaganos, T.
AU - Kotzampassi, K.
AU - Paraschos, M.
AU - Katsenos, C.
AU - Giamarellos-Bourboulis, E.J.
AU - Mandragos, K.
JO - Biomarker Insights
PY - 2016
VL - 21
TODO - 7
SP - 660-664
PB - Taylor and Francis Ltd.
SN - 1177-2719
TODO - 10.3109/1354750X.2016.1171911
TODO - urokinase receptor;  biological marker;  isoprotein;  urokinase receptor, adult;  Article;  bloodstream infection;  female;  Greece;  hospital admission;  human;  intensive care unit;  major clinical study;  male;  multiple organ failure;  multiple trauma;  predictive value;  protein blood level;  blood;  complication;  disease course;  multiple organ failure;  multiple trauma;  odds ratio;  sepsis, Biomarkers;  Disease Progression;  Humans;  Multiple Organ Failure;  Multiple Trauma;  Odds Ratio;  Protein Isoforms;  Receptors, Urokinase Plasminogen Activator;  Sepsis
TODO - Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset. Results: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis. Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
ER -