TY - JOUR
TI - Effects of electronic cigarette on platelet and vascular function after four months of use
AU - Ikonomidis, I.
AU - Katogiannis, K.
AU - Kostelli, G.
AU - Kourea, K.
AU - Kyriakou, E.
AU - Kypraiou, A.
AU - Tsoumani, M.
AU - Andreadou, I.
AU - Lambadiari, V.
AU - Plotas, P.
AU - Thymis, I.
AU - Tsantes, A.E.
JO - Food and Chemical Toxicology
PY - 2020
VL - 141
TODO - null
SP - null
PB - Elsevier Ireland Ltd
SN - 0278-6915, 1873-6351
TODO - 10.1016/j.fct.2020.111389
TODO - carbon monoxide;  malonaldehyde;  nicotine;  nicotine, adult;  arterial stiffness;  artery compliance;  Article;  blood level;  blood vessel function;  breath analysis;  carotid artery;  cigarette smoking;  controlled study;  current smoker;  female;  femoral artery;  human;  human cell;  male;  oxidative stress;  platelet aggregation assay;  pulse wave;  shear stress;  thrombocyte function;  vaping;  drug effect;  electronic cigarette;  physiology;  thrombocyte;  vascular endothelium, Blood Platelets;  Electronic Nicotine Delivery Systems;  Endothelium, Vascular;  Humans;  Nicotine
TODO - We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction < 0.001), improvement of PWV (decrease of 0.8 m/s vs increase of 0.8 m/s, p for interaction = 0.020) and reduction of MDA (reduction 0.13 vs increase 0.19 nmol/L, p for interaction = 0.035). Switching to electronic cigarette for 4 months has a neutral effect on platelet function while it reduces arterial stiffness and oxidative stress compared to tobacco smoking. © 2020 Elsevier Ltd
ER -