TY - JOUR
TI - Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum
AU - Karioti, A.
AU - Skopeliti, M.
AU - Tsitsilonis, O.
AU - Heilmann, J.
AU - Skaltsa, H.
JO - Phytochemistry
PY - 2007
VL - 68
TODO - 11
SP - 1587-1594
PB - 
SN - 0031-9422
TODO - 10.1016/j.phytochem.2007.03.027
TODO - antineoplastic agent;  diterpene;  immunologic factor, article;  cell culture;  cell proliferation;  chemistry;  drug effect;  human;  isolation and purification;  lymphocyte;  Marrubium;  nuclear magnetic resonance;  tumor cell line, Antineoplastic Agents, Phytogenic;  Cell Line, Tumor;  Cell Proliferation;  Cells, Cultured;  Diterpenes;  Humans;  Immunologic Factors;  Lymphocytes;  Marrubium;  Nuclear Magnetic Resonance, Biomolecular, Lamiaceae;  Magnoliophyta;  Marrubium
TODO - From the aerial parts of Marrubium cylleneum, one labdane nor-diterpene has been isolated together with two labdane diterpenes, hitherto not known as natural products. The structures of the isolated compounds were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in standard in vitro assays. Our results show a differential cytotoxicity of some compounds as well as their ability to improve selected lymphocyte functions. © 2007 Elsevier Ltd. All rights reserved.
ER -