TY - JOUR
TI - Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity
AU - Skaltsa, H.
AU - Lazari, D.
AU - Panagouleas, C.
AU - Georgiadou, E.
AU - Garcia, B.
AU - Sokovic, M.
JO - Phytochemistry
PY - 2000
VL - 55
TODO - 8
SP - 903-908
PB - Elsevier Ireland Ltd
SN - 0031-9422
TODO - 10.1016/S0031-9422(00)00254-5
TODO - antifungal agent;  Asteraceae;  atticin;  eudesmane derivative;  eudesmanolide derivative;  lactone;  sesquiterpene;  sesquiterpene lactone derivative;  unclassified drug, antifungal activity;  article;  Aspergillus niger;  controlled study;  dilution;  drug activity;  drug isolation;  drug structure;  nonhuman;  nuclear magnetic resonance spectroscopy;  species difference;  structure activity relation;  structure analysis, Aspergillus niger;  Asteraceae;  Centaurea;  Centaurea attica;  Centaurea attica;  Centaurea thessala;  Centaurea thessala
TODO - The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity. (C) 2000 Elsevier Science Ltd.
ER -