TY - JOUR
TI - Immunostimulation and Coagulopathy in COVID-19 Compared to Patients With H1N1 Pneumonia or Bacterial Sepsis
AU - Papadakis, D.-D.
AU - Politou, M.
AU - Kompoti, M.
AU - Vagionas, D.
AU - Kostakou, E.
AU - Theodoulou, D.
AU - Kaniaris, E.
AU - Rovina, N.
AU - Panayiotakopoulos, G.
AU - Dimopoulos, S.
AU - Koutsoukou, A.
AU - Vasileiadis, I.
JO - In vivo (Athens, Greece)
PY - 2022
VL - 36
TODO - 2
SP - 954-960
PB - NLM (Medline)
SN - null
TODO - 10.21873/invivo.12786
TODO - blood clotting disorder;  complication;  human;  immunization;  Influenza A virus (H1N1);  sepsis, Blood Coagulation Disorders;  COVID-19;  Humans;  Immunization;  Influenza A Virus, H1N1 Subtype;  SARS-CoV-2;  Sepsis
TODO - BACKGROUND/AIM: Multiple reports from all over the world link COVID-19 with endothelial/coagulation disorders as well as a dysregulated immune response. This study tested the hypothesis that immunostimulation will be greater in COVID-19 patients than in patients with H1N1 infection or bacterial sepsis. Also, whether an increase in immune stimulation will be accompanied by a more severely affected endothelium/coagulation system was examined. PATIENTS AND METHODS: Twenty-three septic patients, admitted in the Intensive Care Unit (ICU), were enrolled (9 with SARS-CoV-2, 5 with H1N1 pneumonia, 9 with bacterial sepsis). Myeloperoxidase (MPO) activity along with certain endothelial/coagulation factors were assessed on admission (time point 1) and at either improvement or deterioration (time point 2). RESULTS: MPO levels were significantly higher in COVID-19 patients compared to both other groups. Furthermore, in patients with COVID-19, vWF levels did not differ significantly, fVIII levels were lower while ADAMTS-13 activity was higher compared to patients with H1N1 pneumonia and bacterial sepsis (a trend in the latter). CONCLUSION: Increased immunostimulation was noted in COVID-19 patients compared to other septic patients; however, this was not accompanied by greater disturbance of the clotting system and/or more severe endothelial injury. Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
ER -