TY - JOUR
TI - Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause
AU - Tsoumani, M.
AU - Nikolaou, P.E.
AU - Argyropoulou, A.
AU - Tseti, I.
AU - Mitakou, S.
AU - Andreadou, I.
JO - Molecules
PY - 2022
VL - 27
TODO - 4
SP - null
PB - MDPI
SN - 1420-3049
TODO - 10.3390/molecules27041221
TODO - antioxidant;  estrogen;  phytochemical;  plant extract;  prostaglandin, blood vessel;  chemistry;  dietary supplement;  dose response;  drug effect;  hot flush;  human;  isolation and purification;  menopause;  metabolism;  middle aged;  tumor cell line, Antioxidants;  Blood Vessels;  Cell Line, Tumor;  Dietary Supplements;  Dose-Response Relationship, Drug;  Estrogens;  Hot Flashes;  Humans;  Menopause;  Middle Aged;  Phytochemicals;  Plant Extracts;  Prostaglandins
TODO - Hot flashes are considered the most bothersome complaint during menopause. Although hormone therapy is an effective option to relieve hot flashes, it has been associated with significant side effects. The aim of our study is to suggest a novel combination of different plant extracts with distinct mechanisms of action against hot flashes. We selected the rhizome of Glycyrrhiza glabra L. (Fabaceae), the rhizome of Actaea racemosa L. (Ranunculaceae), the aerial parts of Hypericum perfora-tum L. (Hypericaceae) to produce extracts rich in bioactive phytochemicals and the seed oil of Oe-nothera biennis L. (Onagraceae). We investigated their estrogenic and antioxidant potential and their inhibitory effect against prostaglandin D2 receptor 1 (DP1) as a novel mechanistic pathway for vas-odilation in hot flashes, alone or in combination. The phytochemical footprint of the extracts was analyzed using HPLC-PDA and UPLC-HRMS. We observed that the tested extracts possess different mechanisms of action. A. racemosa exerts a beneficial activation of the estrogen receptor, H. per-foratum possesses the highest antioxidant capacity and the seed oil of O. biennis inhibits the DP1 receptor. The triple combination in the optimal doses pertains to efficacy against all three mechanisms of action, serves as a multitarget plant-based therapy and could serve as a novel strategy for the alleviation of hot flashes in postmenopausal women. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
ER -