TY - JOUR
TI - Individual and combined assessment of ser680asn fsh receptor and fshβ-211 g>t gene polymorphisms in ovarian response in ivf/icsi program
AU - Anagnostou, E.
AU - Kafkoutsou, A.
AU - Mavrogianni, D.
AU - Domali, E.
AU - Dimitroulia, E.
AU - Mathiopoulos, D.
AU - Drakakis, P.
AU - Loutradis, D.
JO - Current Pharmaceutical Biotechnology
PY - 2021
VL - 22
TODO - 14
SP - 1857-1865
PB - Bentham Science Publishers
SN - 1389-2010
TODO - 10.2174/1389201021666201029153518
TODO - buserelin;  chorionic gonadotropin;  estradiol;  estrogen;  follitropin;  follitropin beta subunit;  follitropin receptor;  gonadorelin agonist;  luteinizing hormone;  Muellerian inhibiting factor;  follitropin;  follitropin beta subunit;  follitropin receptor, adult;  Article;  chemiluminescent microparticle immunoassay;  DNA polymorphism;  electrochemiluminescence;  electrochemiluminescence immunoassay;  embryo transfer;  enzyme linked immunosorbent assay;  female;  genetic polymorphism;  genotype;  human;  in vitro fertilization;  intracytoplasmic sperm injection;  oocyte;  oocyte maturation;  ovary hyperstimulation;  ovulation induction;  pregnancy rate;  genetics;  intracytoplasmic sperm injection;  pregnancy;  single nucleotide polymorphism, Female;  Follicle Stimulating Hormone;  Follicle Stimulating Hormone, beta Subunit;  Humans;  Polymorphism, Single Nucleotide;  Pregnancy;  Receptors, FSH;  Sperm Injections, Intracytoplasmic
TODO - Background: Molecular biology tools, such as the detection of Single Nucleotide Polymor-phisms (SNPs), have been considered to assist in the management of ovarian stimulation protocols. Purpose: The aim of this study was to evaluate the impact of two polymorphisms, the Asn680Ser pol-ymorphism of the FSHR gene, and the FSH β subunit (FSHβ) gene polymorphism-211 G>T, in a Greek population of women undergoing IVF/ICSI program in our center. In addition, a control group of fertile women was studied to verify whether there are differences in the genotype distribution between fertile and infertile population for both polymorphisms, as the FSHβ gene polymorphism-211 G>T is studied for the first time in the Greek population. Results: The FSH β-211 G>T polymorphism, studied for the first time in the infertile Greek popula-tion, appears to be quite rare. When studying the two polymorphisms separately, statistically signifi-cant differences were obtained that concerned the LH levels. Discussion: According to the combination analysis of the two polymorphisms by the number of al-leles, women with 2-3 polymorphic alleles needed more days of stimulation, but there were no differences in pregnancy rates. Conclusion: This molecular genetic study helps to elucidate whether the polygenic combination of the Asn680Ser and FSH β subunit-211 G>T gene polymorphisms is of additive value in the prediction of ovarian response to exogenous gonadotropins. © 2021 Bentham Science Publishers.
ER -