TY - JOUR
TI - Impact of K-ras over-expression in laryngeal squamous cell carcinoma
AU - Papanikolaou, V.
AU - Chrysovergis, A.
AU - Mastronikolis, S.
AU - Tsiambas, E.
AU - Ragos, V.
AU - Peschos, D.
AU - Spyropoulou, D.
AU - Pantos, P.
AU - Niotis, A.
AU - Mastronikolis, N.
AU - Kyrodimos, E.
JO - In vivo (Athens, Greece)
PY - 2021
VL - 35
TODO - 3
SP - 1611-1615
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.12418
TODO - antineoplastic agent, alcohol consumption;  Article;  cancer chemotherapy;  cancer diagnosis;  cancer grading;  cancer radiotherapy;  cancer staging;  cancer tissue;  carcinogenesis;  clinical feature;  descriptive research;  digital technology;  female;  gene overexpression;  human;  human tissue;  image analysis;  immunohistochemistry;  larynx;  larynx squamous cell carcinoma;  major clinical study;  male;  oncogene K ras;  phenotype;  primary tumor;  smoking;  tumor differentiation;  tumor volume;  gene expression regulation;  genetics;  head and neck tumor;  larynx tumor;  oncogene ras;  squamous cell carcinoma, Carcinoma, Squamous Cell;  Gene Expression Regulation, Neoplastic;  Genes, ras;  Head and Neck Neoplasms;  Humans;  Laryngeal Neoplasms;  Squamous Cell Carcinoma of Head and Neck
TODO - Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation is a crucial genetic combination that promotes cell neoplastic phenotype and progressively malignant transformation in solid malignancies, including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten ras oncogene homolog (K-Ras) is involved in LSCC onset and progression. Patients and Methods: Sixty (n=60) primary LSCC tissue sections were analyzed by immunohistochemistry (IHC). Digital image analysis (DIA) was also implemented for measuring K-Ras protein expression levels. Results: High KRas protein expression levels were observed in 20/60 (33.3%) LSCC tissue sections, whereas the rest of the cases (n=40; 66.7%) demonstrated low expression. Overall K-Ras expression was borderline significantly associated to the grade of the examined malignancies (p=0.048), whereas no other strong statistical correlations were identified. A progressive K-Ras overexpression was observed in all grades of the examined cases. Conclusion: K-Ras over expression is correlated to a progressive dedifferentiation in LSCC. © 2021 International Institute of Anticancer Research. All rights reserved.
ER -