TY - JOUR
TI - Natural products in drug discovery: advances and opportunities
AU - Atanasov, A.G.
AU - Zotchev, S.B.
AU - Dirsch, V.M.
AU - Orhan, I.E.
AU - Banach, M.
AU - Rollinger, J.M.
AU - Barreca, D.
AU - Weckwerth, W.
AU - Bauer, R.
AU - Bayer, E.A.
AU - Majeed, M.
AU - Bishayee, A.
AU - Bochkov, V.
AU - Bonn, G.K.
AU - Braidy, N.
AU - Bucar, F.
AU - Cifuentes, A.
AU - D’Onofrio, G.
AU - Bodkin, M.
AU - Diederich, M.
AU - Dinkova-Kostova, A.T.
AU - Efferth, T.
AU - El Bairi, K.
AU - Arkells, N.
AU - Fan, T.-P.
AU - Fiebich, B.L.
AU - Freissmuth, M.
AU - Georgiev, M.I.
AU - Gibbons, S.
AU - Godfrey, K.M.
AU - Gruber, C.W.
AU - Heer, J.
AU - Huber, L.A.
AU - Ibanez, E.
AU - Kijjoa, A.
AU - Kiss, A.K.
AU - Lu, A.
AU - Macias, F.A.
AU - Miller, M.J.S.
AU - Mocan, A.
AU - Müller, R.
AU - Nicoletti, F.
AU - Perry, G.
AU - Pittalà, V.
AU - Rastrelli, L.
AU - Ristow, M.
AU - Russo, G.L.
AU - Silva, A.S.
AU - Schuster, D.
AU - Sheridan, H.
AU - Skalicka-Woźniak, K.
AU - Skaltsounis, L.
AU - Sobarzo-Sánchez, E.
AU - Bredt, D.S.
AU - Stuppner, H.
AU - Sureda, A.
AU - Tzvetkov, N.T.
AU - Vacca, R.A.
AU - Aggarwal, B.B.
AU - Battino, M.
AU - Giampieri, F.
AU - Wink, M.
AU - Wolfender, J.-L.
AU - Xiao, J.
AU - Yeung, A.W.K.
AU - Lizard, G.
AU - Popp, M.A.
AU - Heinrich, M.
AU - Berindan-Neagoe, I.
AU - Stadler, M.
AU - Daglia, M.
AU - Verpoorte, R.
AU - Supuran, C.T.
AU - the International Natural Product Sciences Taskforce
JO - Nature Reviews Drug Discovery
PY - 2021
VL - 20
TODO - 3
SP - 200-216
PB - Institute of Geographic Sciences and Natural Resources Research
SN - 1474-1776, 1474-1784
TODO - 10.1038/s41573-020-00114-z
TODO - natural product;  biological product, chromatography;  drug development;  engineering;  liquid chromatography-mass spectrometry;  metabolomics;  mining;  molecular weight;  nonhuman;  nuclear magnetic resonance spectroscopy;  priority journal;  Review;  spectroscopy;  technology;  chemistry;  communicable disease;  drug development;  drug effects;  drug industry;  genetics;  genome;  human;  neoplasm;  procedures, Biological Products;  Communicable Diseases;  Drug Discovery;  Drug Industry;  Genome;  Humans;  Neoplasms
TODO - Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities. © 2021, Springer Nature Limited.
ER -