TY - JOUR
TI - The use of L-glucose in cancer diagnosis: Results from in vitro and in vivo studies
AU - Anastasiou, I.A.
AU - Eleftheriadou, I.
AU - Tentolouris, A.
AU - Mourouzis, I.
AU - Pantos, C.
AU - Tentolouris, N.
JO - Current Medicinal Chemistry
PY - 2021
VL - 28
TODO - 30
SP - 6110-6122
PB - Bentham Science Publishers
SN - 0929-8673
TODO - 10.2174/0929867328666210311112240
TODO - glucose, human;  neoplasm, Glucose;  Humans;  Neoplasms
TODO - Background: Cancer cells are characterized by metabolic heterogeneity. Al-though many research groups make efforts to analyze this heterogeneity, little attention has been paid to cancer cells utilizing otherwise unusable substrates as fuel for tumor de-velopment. Of the two stereoisomers of glucose, D-glucose but not L-glucose, the mirror image isomer of D-glucose is abundantly found in nature. D-glucose is the human body's key source of energy through aerobic respiration. However, data from in vitro and in vivo studies examining the ability of cancer cells to take up L-glucose are scarce. Objectives: The present mini-review aims to present current literature data on the role of L-glucose in cancer diagnosis based on in vitro and in vivo studies. Methods: The MEDLINE, EMBASE, and the Cochrane Library with restrictions to arti-cles in English language databases were searched to retrieve available data. Results: There are limited data in the literature regarding in vitro and in vivo studies that examined the ability of cancer cells to take up L-glucose. Research work so far has shown that that the binding of a fluorescent detector to an L-glucose molecule produced a fluorescent probe that was specifically taken up by malignant cancer cells, thus provid-ing a unique method for their detection. Conclusion: Given that L-glucose is taken up by cancer cells, L-glucose fluorescent probes can be a useful tool for visualization and characterization of cancer cells. More research on the potential biologic effects of L-glucose in cancer is necessary. © 2021 Bentham Science Publishers.
ER -