TY - JOUR
TI - Clinicopathological Data and Treatment Modalities for Pancreatic Somatostatinomas
AU - Mastoraki, A.
AU - Schizas, D.
AU - Papoutsi, E.
AU - Ntella, V.
AU - Kanavidis, P.
AU - Sioulas, A.
AU - Tsoli, M.
AU - Charalampopoulos, G.
AU - Vailas, M.
AU - Felekouras, E.
JO - In vivo (Athens, Greece)
PY - 2020
VL - 34
TODO - 6
SP - 3573-3582
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.12201
TODO - fluorouracil;  mitomycin;  streptozocin, abdominal pain;  adjuvant chemotherapy;  adjuvant therapy;  Article;  backache;  body weight loss;  cancer adjuvant therapy;  cancer diagnosis;  cancer epidemiology;  cancer patient;  cancer surgery;  cancer survival;  cholelithiasis;  clinical feature;  computer assisted tomography;  diabetes mellitus;  distal pancreatectomy;  enucleation;  follow up;  human;  jaundice;  metastasis;  metastasis resection;  multimodality cancer therapy;  overall survival;  pancreas biopsy;  pancreaticoduodenectomy;  somatostatinoma;  steatorrhea;  systematic review;  tumor biopsy;  metastasis resection;  middle aged;  neuroendocrine tumor;  pancreas tumor;  somatostatinoma;  x-ray computed tomography, Humans;  Metastasectomy;  Middle Aged;  Neuroendocrine Tumors;  Pancreatic Neoplasms;  Somatostatinoma;  Tomography, X-Ray Computed
TODO - Background/Aim: Somatostatinomas (SSomas) constitute a rare neuroendocrine tumor. The purpose of this study was to evaluate the current published literature about pancreatic SSomas and report epidemiologic and clinicopathologic data for this entity. Patients and Methods: A combined automated and manual systematic database search of the literature was performed using electronic search engines (Medline PubMed, Scopus, Ovid and Cochrane Library), until February 2020. Statistical analysis was performed using the R language and environment for statistical computing. Results: Overall, the research revealed a total of 36 pancreatic SSoma cases. Patient mean age was 50.25 years. The most common pancreatic location was the pancreatic head (61.8%). The most frequent clinical symptom was abdominal pain (61.1%). Diagnostic algorithm most often included Computed Tomography and biopsy; surgical resection was performed in 28 cases. Out of the 36 cases, 22 had been diagnosed with a metastatic tumor and metastasectomy was performed in 6 patients with a worse overall survival (OS) (p=0.029). In total, OS was 47.74 months. Conclusion: Patients with metastatic disease did not benefit from metastasectomy, but the sample size was small to reach definite conclusions. However, further studies with longer follow-up are needed for a better evaluation of these results. © 2020 International Institute of Anticancer Research. All rights reserved.
ER -