TY - JOUR
TI - The effects of ascorbic acid and U-74389G on renal ischemia-reperfusion injury in a rat model
AU - Zografos, C.G.
AU - Chrysikos, D.
AU - Pittaras, T.
AU - Karampelias, V.
AU - Chairakakis, A.
AU - Galanos, A.
AU - Sfiniadakis, I.
AU - Felekouras, E.
AU - Zografos, G.C.
AU - Sideris, M.
AU - Papadopoulou, K.
AU - Papalois, A.E.
JO - In vivo (Athens, Greece)
PY - 2020
VL - 34
TODO - 5
SP - 2475-2484
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.12063
TODO - 21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione;  alanine aminotransferase;  ascorbic acid;  aspartate aminotransferase;  creatinine;  gamma glutamyltransferase;  malonaldehyde;  tumor necrosis factor;  21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione;  antioxidant;  ascorbic acid;  pregnane derivative, alanine aminotransferase blood level;  animal experiment;  animal model;  animal tissue;  Article;  aspartate aminotransferase blood level;  blood sampling;  controlled study;  creatinine blood level;  drug effect;  enzyme linked immunosorbent assay;  gamma glutamyl transferase blood level;  histology;  histopathology;  kidney function;  kidney injury;  kidney ischemia;  kidney tubule;  male;  nonhuman;  rat;  renal ischemia reperfusion injury;  reperfusion;  time to treatment;  animal;  disease model;  reperfusion injury;  Wistar rat, Animals;  Antioxidants;  Ascorbic Acid;  Disease Models, Animal;  Pregnatrienes;  Rats;  Rats, Wistar;  Reperfusion Injury
TODO - Background/Aim: U-74389G and ascorbic acid protect the cells from oxidation. This study aimed to depict their role in ischemia-reperfusion injury in a renal rat model. Materials and Methods: Sixty Wistars rats were randomized into six groups of 10 animals each. Group A Ischemia 30 min, reperfusion 60 min; Group B Ischemia 30 min, reperfusion 120 min; Group C Ischemia 30 min, ascorbic acid administration, reperfusion 60 min; Group D Ischemia 30 min, ascorbic acid administration, reperfusion 120 min; Group E Ischemia 30 min, U-74389G administration, reperfusion 60 min; Group F Ischemia 30 min, U-74389G administration, reperfusion 120 min. We then collected tissue and blood samples. Results: Histology and the significantly decreased malondialdehyde and tumor necrosis factor-α levels indicated that ascorbic acid was superior to U-74389G, at pre-defined time intervals. Conclusion: Ascorbic acid and U-74389G ameliorated renal damage induced by ischemia-reperfusion injury, suggesting a therapeutic effect. © 2020 International Institute of Anticancer Research. All rights reserved.
ER -