TY - JOUR
TI - Identification of Patients at high risk for postsurgical hypoparathyroidism
AU - Kakava, K.
AU - Tournis, S.
AU - Makris, K.
AU - Papadakis, G.
AU - Kassi, E.
AU - Dontas, I.
AU - Karatzas, T.
JO - In vivo (Athens, Greece)
PY - 2020
VL - 34
TODO - 5
SP - 2973-2980
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.12128
TODO - calcium;  parathyroid hormone;  calcium;  parathyroid hormone, adult;  Article;  clinical observation;  controlled study;  female;  high risk patient;  human;  human tissue;  hypocalcemia;  hypoparathyroidism;  major clinical study;  middle aged;  parathyroid gland;  postoperative complication;  preoperative period;  risk assessment;  sensitivity and specificity;  surgical risk;  thyroid disease;  thyroidectomy;  vitamin D deficiency;  adverse event;  hypocalcemia;  hypoparathyroidism;  postoperative complication;  thyroidectomy, Adult;  Calcium;  Female;  Humans;  Hypocalcemia;  Hypoparathyroidism;  Middle Aged;  Parathyroid Hormone;  Postoperative Complications;  Thyroidectomy
TODO - Background/Aim: Postsurgical hypoparathyroidism (PostHypo) is a common complication after total thyroidectomy. We studied the risk factors associated with PostHypo. Patients and Methods: The study included 109 women, (mean age: 50.7±10.75 years), who underwent total thyroidectomy for thyroid diseases. Results: Based on the development of biochemical hypocalcemia on the first postoperative day following total thyroidectomy, (cCa<8.4 mg/dl), 37 women developed PostHypo and 72 did not. Younger age, a lower preoperative corrected calcium and the presence of parathyroid glands in the specimens were related to the development of PostHypo. Of all patients, 51.4% had a vitamin D deficiency. A parathyroid hormone (PTH) value ≥9.4 pg/ml was 84.9% sensitive and 71.4% specific to predict PostHypo on the 1st postoperative day. A 50% reduction of the PTH value on the 1st postoperative day from the preoperative level could identify patients who develop PostHypo with 76% sensitivity and 75% specificity. Conclusion: PTH postoperative measurement and its alteration from the preoperative level can be used to identify patients who are at increased risk to develop PostHypo. © 2020 International Institute of Anticancer Research. All rights reserved.
ER -