TY - JOUR
TI - Cell-derived microparticles and acute coronary syndromes: Is there a predictive role for microparticles?
AU - Zacharia, E.
AU - Zacharias, K.
AU - Papamikroulis, G.-A.
AU - Bertsias, D.
AU - Miliou, A.
AU - Pallantza, Z.
AU - Papageorgiou, N.
AU - Tousoulis, D.
JO - Current Medicinal Chemistry
PY - 2020
VL - 27
TODO - 27
SP - 4440-4468
PB - Bentham Science Publishers
SN - 0929-8673
TODO - 10.2174/0929867327666191213104841
TODO - biological marker;  thromboplastin, acute coronary syndrome;  adverse outcome;  anticoagulation;  apoptosis;  blood clotting;  cardiac imaging;  coronary angiography;  endothelial microparticle;  erythrocyte;  human;  leukocyte microparticle;  membrane microparticle;  platelet microparticle;  prognosis;  Review;  thrombosis;  leukocyte, Acute Coronary Syndrome;  Blood Coagulation;  Cell-Derived Microparticles;  Humans;  Leukocytes;  Thrombosis
TODO - Background: Despite the recent advances in the treatment of Acute Coronary Syndromes (ACS), patients with ACS are still exposed to an increased risk for adverse cardiovascular events, while their prognosis is difficult to determine. Experimental and clinical studies have shown that cell-derived Microparticles (MPs) are associated with the underlying pathophysiological processes that are respon-sible for atherogenesis and may be causally implicated in the induction of atherothrombosis. Objective: In the present article, we aimed to review the available evidence regarding the predictive role of MPs in patients with ACS. Results: Evidence suggests that endothelial MPs are associated with future adverse cardiovascular events in patients with ACS. Platelet-derived MPs have been excessively studied, since they have been found to trigger the coagulation cascade; however, their role as predictors of future cardiovascular events remains debatable. The role of red blood cell-derived MPs is more intriguing; they have been proposed as markers of ongoing thrombosis in patients with ACS, while previous studies have shown that they have anti-coagulant properties in healthy individuals. Leukocyte-derived MPs may also have a predictive role, although the studies regarding these are still limited. Last but not least, it was an inter-esting discovery that circulating MPs can provide information regarding the angiographic lesions in patients with ACS. Conclusion: The concept of MPs as potential circulating biomarkers in patients with ACS holds much promise. However, large-scale clinical studies are required to evaluate whether the measurement of plasma MPs could be of clinical significance and, thus, dictate a more aggressive treatment strategy in patients with high levels of circulating MPs. © 2020 Bentham Science Publishers.
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