TY - JOUR
TI - Synthesis of diphenoxyadamantane alkylamines with pharmacological interest
AU - Georgiadis, M.-O.
AU - Kourbeli, V.
AU - Ioannidou, V.
AU - Karakitsios, E.
AU - Papanastasiou, I.
AU - Tsotinis, A.
AU - Komiotis, D.
AU - Vocat, A.
AU - Cole, S.T.
AU - Taylor, M.C.
AU - Kelly, J.M.
JO - Bioorganic and Medicinal Chemistry Letters
PY - 2019
VL - 29
TODO - 11
SP - 1278-1281
PB - Elsevier Ireland Ltd
SN - null
TODO - 10.1016/j.bmcl.2019.04.010
TODO - aliphatic amine;  antitrypanosomal agent;  diphenoxyadamantane alkylamine;  tuberculostatic agent;  unclassified drug;  adamantane;  amine;  antitrypanosomal agent;  tuberculostatic agent, antibacterial activity;  Article;  bacterial growth;  controlled study;  drug structure;  drug synthesis;  growth inhibition;  Mycobacterium tuberculosis;  nonhuman;  trypanocidal activity;  Trypanosoma brucei;  chemical structure;  chemistry;  dose response;  drug effect;  drug sensitivity;  structure activity relation;  synthesis;  Trypanosoma brucei brucei, Adamantane;  Amines;  Antitubercular Agents;  Dose-Response Relationship, Drug;  Molecular Structure;  Mycobacterium tuberculosis;  Parasitic Sensitivity Tests;  Structure-Activity Relationship;  Trypanocidal Agents;  Trypanosoma brucei brucei
TODO - In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia–f and IIa–f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity. © 2019 Elsevier Ltd
ER -