TY - JOUR
TI - Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists†
AU - Tsotinis, A.
AU - Kompogennitaki, R.
AU - Papanastasiou, I.
AU - Garratt, P.J.
AU - Bocianowska, A.
AU - Sugden, D.
JO - MedChemComm
PY - 2019
VL - null
TODO - null
SP - 460-464
PB - Royal Society of Chemistry
SN - 2040-2503, 2040-2511
TODO - 10.1039/c8md00604k
TODO - amide;  fluorine;  melatonin;  melatonin receptor agonist;  methoxyphenylalkyl amide derivative;  unclassified drug, Article;  bioassay;  chemical modification;  concentration response;  controlled study;  drug potency;  drug structure;  drug synthesis;  melanophore;  nonhuman;  priority journal;  reaction analysis;  structure activity relation;  Xenopus
TODO - A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n = 1-3). β-Dimethyl and α-methyl derivatives were also synthesised. The compounds were tested as melatonin agonists and antagonists using the pigment aggregation of Xenopus melanophores as the biological assay. A number of these compounds were potent melatonin agonists, the potency depending on the length of the alkyl chain, the orientation of the methoxy and fluorine substituents, the amide chain length and, for the ethyl side-chain analogues, the presence of β-substituents. © The Royal Society of Chemistry 2019
ER -