TY - JOUR
TI - The role of adipokines in the establishment and progression of head and neck neoplasms
AU - Tzanavari, T.
AU - Tasoulas, J.
AU - Vakaki, C.
AU - Mihailidou, C.
AU - Tsourouflis, G.
AU - Theocharis, S.
JO - Current Medicinal Chemistry
PY - 2019
VL - 26
TODO - 25
SP - 4726-4748
PB - Bentham Science Publishers
SN - 0929-8673
TODO - 10.2174/0929867325666180713154505
TODO - adipocytokine;  adipocytokine receptor;  adiponectin;  chemerin;  ghrelin;  glucose;  Janus kinase;  leptin;  mammalian target of rapamycin;  nicotinamide phosphoribosyltransferase;  peroxisome proliferator activated receptor;  phosphatidylinositol 3 kinase;  protein kinase B;  resistin;  STAT protein;  tumor marker;  adipocytokine;  antineoplastic agent;  tumor marker, Akt signaling;  angiogenesis;  apoptosis;  cancer prognosis;  carcinogenesis;  cell proliferation;  esophageal squamous cell carcinoma;  esophagus cancer;  gene expression regulation;  glucose homeostasis;  head and neck tumor;  human;  inflammation;  JAK-STAT signaling;  larynx squamous cell carcinoma;  mouth cancer;  Review;  salivary gland cancer;  thyroid cancer;  tumor growth;  white adipose tissue;  head and neck tumor, Adipokines;  Antineoplastic Agents;  Biomarkers, Tumor;  Head and Neck Neoplasms;  Humans
TODO - Adipokines constitute a family of protein factors secreted by white adipose tissue (WAT), that regulate the functions of WAT and other sites. Leptin, adiponectin and resistin, are the main adipokines present in serum and saliva, targeting several tissues and organs, including vessels, muscles, liver and pancreas. Besides body mass regulation, adipokines affect glucose homeostasis, inflammation, angiogenesis, cell proliferation and apoptosis, and other crucial cell procedures. Their involvement in tumor formation and growth is well established and deregulation of adipokine and adipokine receptors' expression is observed in several malignancies including those located in the head and neck region. Intracellular effects of adipokines are mediated by a plethora of receptors that activate several signaling cascades including Janus kinase/ Signal transducer and activator of transcription (JAK/ STAT pathway), Phospatidylinositol kinase (PI3/ Akt/ mTOR) and Peroxisome proliferator-activated receptor (PPAR). The present review summarizes the current knowledge on the role of adipokines family members in carcinogenesis of the head and neck region. The diagnostic and prognostic significance of adipokines and their potential role as serum and saliva biomarkers are also discussed. © 2019 Bentham Science Publishers.
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