TY - JOUR
TI - An adult patient with early Pre-B acute lymphoblastic leukemia with t(12;17)(p13;q21)/ZNF384-TAF15
AU - Georgakopoulos, N.
AU - Diamantopoulos, P.
AU - Micci, F.
AU - Giannakopoulou, N.
AU - Zervakis, K.
AU - Dimitrakopoulou, A.
AU - Viniou, N.-A.
JO - In vivo (Athens, Greece)
PY - 2018
VL - 32
TODO - 5
SP - 1241-1245
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.11371
TODO - CD123 antigen;  CD19 antigen;  CD34 antigen;  CD79a antigen;  common acute lymphoblastic leukemia antigen;  DNA binding protein;  HLA DR antigen;  lactate dehydrogenase;  meropenem;  microsomal aminopeptidase;  protein;  RNA binding protein;  taf15 protein;  tdt protein;  unclassified drug;  uric acid;  vancomycin;  zinc finger protein;  zinc finger protein 384;  biological marker;  oncoprotein;  TAF15 protein, human;  TATA binding protein associated factor;  transactivator protein;  ZNF384 protein, human, acute lymphoblastic leukemia;  adult;  Article;  autosome;  B cell leukemia;  blood culture;  blood smear;  bone marrow biopsy;  case report;  cerebrospinal fluid analysis;  chromosome 14p;  chromosome aberration;  chromosome analysis;  chromosome G band;  chromosome translocation;  clinical article;  clinical examination;  early cancer;  febrile neutropenia;  fever;  gene fusion;  gene rearrangement;  Gram negative sepsis;  human;  karyotype 46,XY;  kidney injury;  lactate dehydrogenase blood level;  leukemogenesis;  leukocytosis;  malaise;  male;  medical history;  metaphase;  metaphase chromosome;  middle aged;  molecular pathology;  normochromic normocytic anemia;  rhabdomyolysis;  septic shock;  thrombocytopenia;  uric acid blood level;  urine culture;  acute lymphoblastic leukemia;  blood cell count;  chromosome 12;  chromosome 17;  chromosome banding pattern;  fluorescence in situ hybridization;  gene translocation;  genetics;  immunophenotyping, Biomarkers;  Blood Cell Count;  Chromosome Banding;  Chromosomes, Human, Pair 12;  Chromosomes, Human, Pair 17;  Humans;  Immunophenotyping;  In Situ Hybridization, Fluorescence;  Male;  Middle Aged;  Oncogene Proteins, Fusion;  Precursor B-Cell Lymphoblastic Leukemia-Lymphoma;  TATA-Binding Protein Associated Factors;  Trans-Activators;  Translocation, Genetic
TODO - This is a case report of a 46-year-old man diagnosed with early pre-B acute lymphoblastic leukemia (ALL), bearing the translocation t(12;17)(p13;q21) as the sole chromosomal abnormality. This is a rare chromosomal abnormality that has been reported in approximately 25 cases worldwide. FISH analysis revealed a rearrangement of ZNF384 (12p13) and TAF15 (17q12) genes, which is usually associated with a pre-B ALL phenotype with coexpression of the myeloid markers CD13 and/or CD33. ZNF384 encodes a zinc finger protein, which acts as a transcription factor, regulating the expression of several matrix metalloproteinases and TAF15 belongs to the FET (FUS, EWS, and TAF15) family, consisting of RNA and DNA-binding proteins. Unlike most of the cases where CD10 expression was absent or weak, in our case CD10 was highly expressed. The prognostic significance of ZNF384/TAF15 fusion is not very clear since several reports support a generally good prognosis, while others support a poor clinical outcome. Our patient was treated with the German multicenter ALL (GMALL) protocol for B-ALL, but experienced a fulminant gram-negative sepsis and eventually died during induction therapy. © 2018 Institute of Electrical and Electronics Engineers Inc. All rights reserved.
ER -