TY - JOUR
TI - Expression of miR-208b and miR-499 in greek patients with acute myocardial infarction
AU - Agiannitopoulos, K.
AU - Pavlopoulou, P.
AU - Tsamis, K.
AU - Bampali, K.
AU - Samara, P.
AU - Nasioulas, G.
AU - Mertzanos, G.
AU - Babalis, D.
AU - Lamnissou, K.
JO - In vivo (Athens, Greece)
PY - 2018
VL - 32
TODO - 2
SP - 313-318
PB - International Institute of Anticancer Research
SN - null
TODO - 10.21873/invivo.11239
TODO - amino terminal pro brain natriuretic peptide;  creatine kinase MB;  creatinine;  glucose;  high density lipoprotein;  low density lipoprotein;  microRNA;  microRNA 208b;  microRNA 499;  triacylglycerol;  troponin T;  unclassified drug;  biological marker;  circulating microRNA;  microRNA;  MIRN208 microRNA, human;  MIRN499 microRNA, human, acute heart infarction;  adult;  Article;  blood analysis;  blood sampling;  clinical evaluation;  comparative study;  concentration process;  controlled study;  diagnostic value;  female;  genetic analysis;  Greece;  histopathology;  human;  major clinical study;  male;  microanalysis;  population;  receiver operating characteristic;  aged;  blood;  case control study;  gene expression;  gene expression profiling;  genetics;  heart infarction;  liquid biopsy;  middle aged;  risk factor, Aged;  Biomarkers;  Case-Control Studies;  Circulating MicroRNA;  Female;  Gene Expression;  Gene Expression Profiling;  Greece;  Humans;  Liquid Biopsy;  Male;  MicroRNAs;  Middle Aged;  Myocardial Infarction;  Risk Factors;  ROC Curve
TODO - Background/Aim: Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population. Materials and Methods: Plasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays. Results: The concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT). Conclusion: We showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers. © 2018 International Institute of Anticancer Research. All Rights Reserved.
ER -