TY - JOUR
TI - Associations between adiponectin gene variability, pro-inflammatory and angiogenetic markers: Implications for microvascular disease development in type 2 diabetes mellitus?
AU - Kollia, C.
AU - Antonopoulos, A.S.
AU - Siasos, G.
AU - Konsola, T.
AU - Oikonomou, E.
AU - Gouliopoulos, N.
AU - Tsigkou, V.
AU - Papapanagiotou, A.
AU - Kassi, E.
AU - Tentolouris, N.
AU - Katsiki, N.
AU - Vavuranakis, M.
AU - Papavassiliou, A.G.
AU - Tousoulis, D.
JO - Current Vascular Pharmacology
PY - 2018
VL - 17
TODO - 2
SP - 204-208
PB - Bentham Science Publishers B.V.
SN - 1570-1611
TODO - 10.2174/1570161116666180108113825
TODO - adiponectin;  angiogenic protein;  C reactive protein;  hemoglobin A1c;  intercellular adhesion molecule 1;  interleukin 6;  vasculotropin;  adiponectin;  ADIPOQ protein, human;  autacoid;  biological marker;  C reactive protein;  ICAM1 protein, human;  IL6 protein, human;  intercellular adhesion molecule 1;  interleukin 6;  vasculotropin A;  VEGFA protein, human, aged;  Article;  body mass;  cholesterol blood level;  coronary artery disease;  disease course;  disease duration;  dyslipidemia;  enzyme linked immunosorbent assay;  family history;  female;  gene frequency;  genetic association;  genetic variability;  genotype;  human;  hypertension;  inflammation;  major clinical study;  male;  microangiopathy;  nephelometry;  non insulin dependent diabetes mellitus;  polymerase chain reaction;  risk factor;  single nucleotide polymorphism;  angiogenesis;  blood;  cross-sectional study;  diabetic angiopathy;  genetics;  non insulin dependent diabetes mellitus;  pathophysiology;  risk assessment;  single nucleotide polymorphism, Adiponectin;  Aged;  Biomarkers;  C-Reactive Protein;  Cross-Sectional Studies;  Diabetes Mellitus, Type 2;  Diabetic Angiopathies;  Female;  Humans;  Inflammation Mediators;  Intercellular Adhesion Molecule-1;  Interleukin-6;  Male;  Neovascularization, Physiologic;  Polymorphism, Single Nucleotide;  Risk Assessment;  Risk Factors;  Vascular Endothelial Growth Factor A
TODO - Background: Adiponectin gene (ADIPOQ) variability may affect the risk for type 2 diabetes mellitus (T2DM) but it remains unclear whether it is involved in microvascular complications. Objective: To explore the impact of ADIPOQ variability on markers of inflammation and angiogenesis in T2DM. Methods: Overall, 220 consecutive T2DM patients from our outpatient diabetic clinic were genotyped for G276T (rs1501299) and T45G (rs2241766) single nucleotide polymorphisms of ADIPOQ gene. Serum levels of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF) were measured by enzyme-linked immunosorbent assay and high sensitivity C-reactive protein (hsCRP) by immunonephelometry. Results: Homozygosity for the G allele on rs2241766 was associated with significantly lower serum VEGF and ICAM-1 levels compared with other genotype groups, but had no effect on IL-6. Genetic variability on rs1501299 was not associated with either VEGF or ICAM-1 levels, but T homozygotes for rs1501299 had significantly lower IL-6 concentrations compared with G carriers. Furthermore, the presence of the G allele on rs2241766 was associated with significantly lower HbA1c, whereas no associations were observed for both body mass index and hsCRP with either rs2241766 or rs1501299. Conclusion: Genetic variability on adiponectin gene was associated with serum levels of inflammatory and angiogenetic markers. Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients. © 2019 Bentham Science Publishers.
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