TY - JOUR
TI - Critical role of IL-8 targeting in gliomas
AU - Kosmopoulos, M.
AU - Christofides, A.
AU - Drekolias, D.
AU - Zavras, P.D.
AU - Gargalionis, A.N.
AU - Piperi, C.
JO - Current Medicinal Chemistry
PY - 2018
VL - 25
TODO - 17
SP - 1954-1967
PB - Bentham Science Publishers B.V.
SN - 0929-8673
TODO - 10.2174/0929867325666171129125712
TODO - biological marker;  cediranib;  dehydroxymethylepoxyquinomicin;  interleukin 6;  interleukin 8;  transforming growth factor beta;  tumor necrosis factor;  antineoplastic agent;  IL8 protein, human;  interleukin 8;  tumor marker, angiogenesis;  astrocyte cell line;  cell migration;  chemoradiotherapy;  data base;  early diagnosis;  follow up;  glioblastoma;  glioma;  glioma cell;  human;  pathogenesis;  Review;  animal;  antagonists and inhibitors;  carcinogenesis;  cell motion;  chemically induced;  down regulation;  drug effect;  genetics;  glioma;  metabolism;  neovascularization (pathology), Animals;  Antineoplastic Agents;  Biomarkers, Tumor;  Carcinogenesis;  Cell Movement;  Down-Regulation;  Glioma;  Humans;  Interleukin-8;  Neovascularization, Pathologic
TODO - Background: Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas. Objective: The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy. Methods and Results: PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy. Conclusion: Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms. © 2018 Bentham Science Publishers.
ER -