TY - JOUR
TI - Diabetes mellitus, hypertension and hypercholesterolemia in relation to the 10-year ACS prognosis; the GREECS study
AU - Notara, V.
AU - Panagiotakos, D.B.
AU - Michalopoulou, M.
AU - Kouvari, M.
AU - Tsompanaki, E.
AU - Verdi, M.
AU - Vassileiou, N.
AU - Kalli, E.
AU - Mantas, Y.
AU - Kogias, Y.
AU - Stravopodis, P.
AU - Papanagnou, G.
AU - Zombolos, S.
AU - Pitsavos, C.
AU - Antonoulas, Y.
AU - Karanasios, A.
AU - Rizos, L.
AU - Mparmparoussis, M.
AU - Kassimatis, G.
AU - Giannopoulos, G.
AU - Arapi, S.
AU - Gialernios, T.
AU - Massoura, C.
AU - Sideris, S.
AU - Daskalopoulos, N.
AU - Stefanadis, C.
AU - Papataxiarchis, E.
AU - Tzanoglou, D.
AU - Kouli, G.
AU - Kouroupi, S.
AU - Balli, M.
AU - Vassileiou, N.
AU - Tsomboli, V.
AU - Chalamandaris, A.
AU - for the GREECS Study Investigators
JO - Current Vascular Pharmacology
PY - 2016
VL - 14
TODO - 3
SP - 295-301
PB - Bentham Science Publishers
SN - 1570-1611
TODO - 10.2174/1570161113666150916093451
TODO - antidiabetic agent;  biochemical marker;  cholesterol;  creatine kinase;  glucose;  troponin I;  glucose blood level, acute coronary syndrome;  acute heart infarction;  adult;  aged;  angioplasty;  Article;  bioethics;  diabetes mellitus;  electrocardiography;  female;  follow up;  food frequency questionnaire;  heart injury;  heart muscle necrosis;  human;  hypercholesterolemia;  hypertension;  International Classification of Diseases;  lifestyle;  longitudinal study;  major clinical study;  male;  mortality rate;  obesity;  observational study;  physical activity;  prognosis;  risk factor;  ST segment depression;  ST segment elevation;  unstable angina pectoris;  acute coronary syndrome;  complication;  diabetes mellitus;  glucose blood level;  hospital mortality;  hypercholesterolemia;  hypertension;  incidence;  pathology;  physiology;  statistical model, Acute Coronary Syndrome;  Aged;  Blood Glucose;  Diabetes Mellitus;  Female;  Hospital Mortality;  Humans;  Hypercholesterolemia;  Hypertension;  Incidence;  Logistic Models;  Longitudinal Studies;  Male;  Prognosis;  Risk Factors
TODO - Although hypertension, hypercholesterolemia and diabetes mellitus (DM) are recognized as major cardio-metabolic risk factors in primary Acute Coronary Syndrome (ACS) prevention, studies focusing on secondary ACS incidence are scarce. In the present study, the association between the aforementioned factors and 10-year ACS prognosis was evaluated. From October 2003 to September 2004 2,172 consecutive patients with ACS diagnosis, from 6 Greek hospitals, were enrolled. During 2013-14, the 10-year follow-up was performed in 1,918 participants. Baseline clinical factors were assessed through physical examination, medical records and pharmacological management. All-cause mortality and the development of fatal or non-fatal ACS events were recorded through medical records or hospital registries. Logistic regression models were applied to evaluate the impact of baseline clinical status on the ACS prognosis. The 10-year all cause and ACS mortality rate was 32.6 and 17.8%, respectively. Multi-adjusted analysis highlighted that, after taking into account various potential confounders, DM was the sole clinical factor associated with adverse effect on the 10-year ACS fatal incidence [Odds Ratio (OR)=1.35, 95% Confidence Interval (95% CI) 1.01, 1.80, p=0.04]. DM was the only clinical factor that aggravated ACS prognosis, whereas abnormal lipids profile and blood pressure did not seem to determine prognosis. Thus, glycaemic control may play a critical role in the secondary CVD prevention management of ACS patients. © 2016 Bentham Science Publishers.
ER -