TY - JOUR
TI - Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity
AU - Konstantinopoulou, M.
AU - Karioti, A.
AU - Skaltsas, S.
AU - Skaltsa, H.
JO - Tropical Journal of Natural Product Research
PY - 2003
VL - 66
TODO - 5
SP - 699-702
PB - 
SN - null
TODO - 10.1021/np020472m
TODO - 1 epitatridin;  1alpha,10beta epoxy 6 hydroxy 1,10h inunolide;  6 hydroxyquercetin 3,6,4' trimethyl ether;  altissin;  apigenin;  chlorogenic acid;  deacetyl beta cyclopyrethrosin;  eriodictyol;  flavonoid;  isoquercetrin;  isorhamnetin;  kaempferol 4' methyl ether;  kaempferol derivative;  phenol derivative;  plant extract;  quercetin;  quercetin 3 methyl ether;  rhamnetin;  sesquiterpene lactone;  sivasinolide;  spiciformin;  tatridin a;  taxifolin;  unclassified drug, Anthemis altissima;  antibacterial activity;  article;  carbon nuclear magnetic resonance;  drug isolation;  drug structure;  Gram negative bacterium;  Gram positive bacterium;  Helicobacter pylori;  medicinal plant;  minimum inhibitory concentration;  nonhuman;  phytochemistry;  proton nuclear magnetic resonance;  stereochemistry, Asteraceae;  Gram-Negative Bacteria;  Gram-Positive Bacteria;  Greece;  Helicobacter pylori;  Lactones;  Microbial Sensitivity Tests;  Molecular Structure;  Nuclear Magnetic Resonance, Biomolecular;  Plants, Medicinal;  Sesquiterpenes;  Stereoisomerism, Anthemis altissima;  Bacteria (microorganisms);  Helicobacter pylori;  Negibacteria;  Posibacteria
TODO - Seven sesquiterpene lactones, (-) sivasinolide (1), a new naturally occurring eudesmanolide (altissin, 2), desacetyl-β-cyclopyrethrosin (3), tatridin-A (4), 1-epi-tatridin B (5), 1α,10β-epoxy-6-hydroxy-1,10H-inunolide (6), and spiciformin (7), were isolated from Anthemis altissima. Also isolated were 10 known flavonoids, namely, apigenin (8), kaempferol 4′-methyl ether (9), quercetin (10), quercetin 3-methyl ether (11), isorhamnetin (12), rhamnetin (13), 6-hydroxyquercetin 3,6,4′-trimethyl ether (14), isoquercetrin (15), taxifolin (16), and eriodictyol (17), and one phenolic acid, chlorogenic acid (18). The structure and the stereochemistry of compound 2 were deduced by spectroscopic methods. The in vitro activity of the sesquiterpene lactones (1-5) against Helicobacter pylori, as well as against three Gram-positive and three Gram-negative bacteria growing aerobically, was tested using the microdilution method. Compounds 8-18 have also been tested against H. pylori.
ER -