TY - JOUR
TI - Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: An effect reversed by thyroxine pretreatment
AU - Pantos, C.
AU - Mourouzis, I.
AU - Tzeis, S.
AU - Moraitis, P.
AU - Malliopoulou, V.
AU - Cokkinos, D.D.
AU - Carageorgiou, H.
AU - Varonos, D.
AU - Cokkinos, D.
JO - European Journal of Pharmacology
PY - 2003
VL - 460
TODO - 2-3
SP - 155-161
PB - Elsevier
SN - 0014-2999
TODO - 10.1016/S0014-2999(02)02927-8
TODO - dobutamine;  propranolol;  thyroxine, animal tissue;  article;  controlled study;  convalescence;  disease exacerbation;  drug effect;  heart function;  heart muscle ischemia;  heart muscle reperfusion;  long term care;  nonhuman;  priority journal;  rat
TODO - The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 μg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 μg 100 g-1 body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction. © 2003 Elsevier Science B.V. All rights reserved.
ER -