TY - JOUR
TI - Does stress influence ampicillin concentration in serum and tissues?
AU - Tesseromatis, C.
AU - Trichilis, A.
AU - Tsivos, E.
AU - Messari, J.
AU - Triantaphyllidis, H.
AU - Varonos, D.D.
JO - European Journal of Drug Metabolism and Pharmacokinetics
PY - 2001
VL - 26
TODO - 3
SP - 167-171
PB - Editions Medecine et Hygiene
SN - 0378-7966, 2107-0180
TODO - 10.1007/BF03190392
TODO - albumin;  ampicillin;  fatty acid, adrenal gland;  animal experiment;  animal model;  animal tissue;  article;  binding affinity;  controlled study;  dose response;  drug binding;  drug blood level;  drug elimination;  drug tissue level;  exercise;  male;  nonhuman;  organ weight;  protein binding;  rat;  stress;  swimming
TODO - Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4°C) for 5, 10, 15, 20, 25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls.
ER -