TY - JOUR
TI - The influence of hydrophobic blocks of PEO-containing copolymers on glyceryl monooleate lyotropic liquid crystalline nanoparticles for drug delivery
AU - Forys, A.
AU - Chountoulesi, M.
AU - Mendrek, B.
AU - Konieczny, T.
AU - Sentoukas, T.
AU - Godzierz, M.
AU - Kordyka, A.
AU - Demetzos, C.
AU - Pispas, S.
AU - Trzebicka, B.
JO - Polym. Chem.
PY - 2021
VL - 13
TODO - 16
SP - null
PB - MDPI AG
SN - null
TODO - 10.3390/polym13162607
TODO - Aliphatic compounds;  Block copolymers;  Colloids;  Dynamic light scattering;  Ethylene;  Fast Fourier transforms;  High resolution transmission electron microscopy;  Hydrophobicity;  Liquid crystals;  Molar ratio;  Nanoparticles;  Nanosystems;  Polyethylene oxides, Amphiphilic block copolymers;  Colloidal dispersion;  Copolymer compositions;  Cryogenic transmission electron microscopy (cryo-TEM);  Glyceryl monooleate;  Lyotropic liquid crystalline;  Morphological characteristic;  Polymeric stabilizers, Drug delivery
TODO - The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use am-phiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octa-decenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, de-pending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/li-pid nanostructures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ER -