TY - JOUR
TI - V1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione
AU - Pardali, V.
AU - Katsamakas, S.
AU - Giannakopoulou, E.
AU - Zoidis, G.
JO - MolBank
PY - 2021
VL - 2021
TODO - 2
SP - null
PB - MDPI AG
SN - null
TODO - 10.3390/M1228
TODO - null
TODO - A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5] decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ER -