TY - JOUR
TI - Fabrication and Characterization of Neurocompatible Ulvan-Based Layer-by-Layer Films
AU - Moon, H.C.
AU - Choi, H.
AU - Kikionis, S.
AU - Seo, J.
AU - Youn, W.
AU - Ioannou, E.
AU - Han, S.Y.
AU - Cho, H.
AU - Roussis, V.
AU - Choi, I.S.
JO - Langmuir
PY - 2020
VL - 36
TODO - 39
SP - 11610-11617
PB - American Chemical Society
SN - 0743-7463, 1520-5827
TODO - 10.1021/acs.langmuir.0c02173
TODO - Adhesion;  Amino acids;  Neurons, Compositional similarities;  Extracellular matrices;  Fabrication and characterizations;  Glycosaminoglycans;  Layer-by-layer films;  Neurite outgrowth;  Primary hippocampal neurons;  Sulfated polysaccharides, Fabrication
TODO - Construction of extracellular matrix-mimetic nanofilms has considerable potential in biomedical and nanomedicinal fields. In this work, we fabricated neurocompatible layer-by-layer (LbL) films based on ulvan (ULV), a highly sulfated polysaccharide having compositional similarity to glycosaminoglycans that play important functional roles in the brain. ULV was durably assembled as a film with chitosan, another marine-derived polysaccharide, and the film enabled the stable adhesion of primary hippocampal neurons with high viability, comparable to the conventional poly-d-lysine surface. Notably, the ULV-based LbL films accelerated neurite outgrowth and selectively suppressed the adhesion of astrocytes, highlighting its potential as an advanced platform for neural implants and devices. © 2020 American Chemical Society.
ER -