TY - JOUR TI - Design and synthesis of some new pyranoxanthenones with cytotoxic activity AU - Ghirtis, K. AU - Pouli, N. AU - Marakos, P. AU - Skaltsounis, A.-L. AU - Leonce, S. AU - Atassi, G. AU - Caignard, D.H. JO - Journal of Heterocyclic Chemistry PY - 2001 VL - 38 TODO - 1 SP - 147-152 PB - SN - 0022-152X, 1943-5193 TODO - 10.1002/jhet.5570380121 TODO - acronine; bromine derivative; cytotoxic agent; pyranoxanthone derivative; unclassified drug, animal cell; article; cell proliferation; drug cytotoxicity; drug design; drug synthesis; mouse; nonhuman; reaction analysis; structure analysis TODO - As part of a research program directed towards the design and synthesis of pyranoxanthones structurally related to acronycine, we present here the synthesis and cytotoxic activity of the pyranoxanthones 3 and 4 (X= H, Br; R= H, OMe; R'= H, Ac). Some of these compounds inhibit L1210 cell proliferation. ER -