TY - JOUR TI - The COVID-19 Pandemic and the Need for an Integrated and Equitable Approach: An International Expert Consensus Paper AU - Gerotziafas, Grigoris T. AU - Catalano, Mariella AU - Theodorou, Yiannis AU - and Van Dreden, Patrick AU - Marechal, Vincent AU - Spyropoulos, Alex C. AU - and Carter, Charles AU - Jabeen, Nusrat AU - Harenberg, Job AU - Elalamy, AU - Ismail AU - Falanga, Anna AU - Fareed, Jawed AU - Agathaggelou, Petros and AU - Antic, Darko AU - Antignani, Pier Luigi AU - Bosch, Manuel Monreal and AU - Brenner, Benjamin AU - Chekhonin, Vladimir AU - Colgan, Mary-Paula and AU - Dimopoulos, Meletios-Athanasios AU - Douketis, Jim AU - Elnazar, Essam Abo AU - and Farkas, Katalin AU - Fazeli, Bahare AU - Fowkes, Gerry AU - Gu, AU - Yongquan AU - Gligorov, Joseph AU - Ligocki, Mark A. AU - Indran, Tishya AU - and Kannan, Meganathan AU - Kantarcioglu, Bulent AU - Kasse, Abdoul Aziz AU - and Konstantinidis, Kostantinos AU - Leivano, Fabio AU - Lewis, Joseph and AU - Makatsariya, Alexander AU - Mbaye, P. Massamba AU - Mahe, Isabelle and AU - Panovska-Stavridis, Irina AU - Olinic, Dan-Mircea AU - Papageorgiou, AU - Chryssa AU - Pecsvarady, Zsolt AU - Pillon, Sergio AU - Ramacciotti, AU - Eduardo AU - Abdel-Razeq, Hikmat AU - Sabbah, Michele AU - Sassi, Mouna and AU - Schernthaner, Gerit AU - Siddiqui, Fakiha AU - Shiomura, Jin and AU - Slama-Schwok, Anny AU - Wautrecht, Jean Claude AU - Tafur, Alfonso and AU - Taher, Ali AU - Klein-Wegel, Peter AU - Zhai, Zenguo AU - Zoubida, Tazi AU - Mezalek JO - Thrombosis and Haemostasis PY - 2021 VL - 121 TODO - 08 SP - 992-1007 PB - Georg Thieme Verlag KG SN - 0340-6245 TODO - 10.1055/a-1535-8807 TODO - COVID-19; SARS-CoV-2; pandemic; thrombosis; health care systems TODO - Background One year after the declaration of the coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization (WHO) and despite the implementation of mandatory physical barriers and social distancing, humanity remains challenged by a long-lasting and devastating public health crisis. Management Non-pharmacological interventions (NPIs) are efficient mitigation strategies. The success of these NPIs is dependent on the approval and commitment of the population. The launch of a mass vaccination program in many countries in late December 2020 with mRNA vaccines, adenovirus-based vaccines, and inactivated virus vaccines has generated hope for the end of the pandemic. Current Issues The continuous appearance of new pathogenic viral strains and the ability of vaccines to prevent infection and transmission raise important concerns as we try to achieve community immunity against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and its variants. The need of a second and even third generation of vaccines has already been acknowledged by the WHO and governments. Perspectives There is a critical and urgent need for a balanced and integrated strategy for the management of the COVID-19 outbreaks organized on three axes: (1) P revention of the SARS-CoV-2 infection, (2) Detection and early diagnosis of patients at risk of disease worsening, and (3) Anticipation of medical care (PDA). Conclusion The “PDA strategy” integrated into state policy for the support and expansion of health systems and introduction of digital organizations (i.e., telemedicine, e-Health, artificial intelligence, and machine-learning technology) is of major importance for the preservation of citizens’ health and life world-wide. ER -