TY - JOUR
TI - The effects of aging on molecular modulators of human embryo
implantation
AU - Ntostis, Panagiotis
AU - Swanson, Grace
AU - Kokkali, Georgia
AU - Iles,
AU - David
AU - Huntriss, John
AU - Pantou, Agni
AU - Tzetis, Maria
AU - Pantos,
AU - Konstantinos
AU - Picton, Helen M.
AU - Krawetz, Stephen A.
AU - Miller,
AU - David
JO - ISCIENCE
PY - 2021
VL - 24
TODO - 7
SP - null
PB - Cell Press
SN - null
TODO - 10.1016/j.isci.2021.102751
TODO - null
TODO - Advancing age has a negative impact on female fertility. As implantation
rates decline during the normal maternal life course, age-related,
embryonic factors are altered and our inability to monitor these factors
in an unbiased genome-wide manner in vivo has severely limited our
understanding of early human embryo development and implantation. Our
high-throughput methodology uses trophectoderm samples representing the
full spectrum of maternal reproductive ages with embryo implantation
potential examined in relation to trophectoderm transcriptome dynamics
and reproductive maternal age. Potential embryo-endometrial interactions
were tested using trophectoderm sampled from young women, with the
receptive uterine environment representing the most `fertile'
environment for successful embryo implantation. Potential roles for
extracellular exosomes, embryonic metabolism and regulation of apoptosis
were revealed. These biomarkers are consistent with embryo-endometrial
crosstalk/developmental competency, serving as a mediator for successful
implantation. Our data opens the door to developing a diagnostic test
for predicting implantation success in women undergoing fertility
treatment.
ER -