TY - JOUR
TI - The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation
Exposure in Interventional Cardiology
AU - Habibi, Martha
AU - Karyofyllis, Panagiotis K.
AU - Nikolakopoulou,
AU - Aggeliki
AU - Papagiannis, Panagiotis
AU - Karaiskos, Pantelis and
AU - Georgakilas, Alexandros G.
AU - Hatzi, I, Vasiliki
AU - Malakos, Ioannis
AU - and Kollaros, Nikolaos
AU - Mastorakou, Irene
AU - Voudris, Vassilis and
AU - Terzoudi, I, Georgia
JO - Frontiers in public health
PY - 2021
VL - 9
TODO - null
SP - null
PB - Frontiers Media SA
SN - 2296-2565
TODO - 10.3389/fpubh.2021.701878
TODO - gamma-H2AX foci; chromosomal aberrations; cardiac interventional
procedures; low dose radiation effects; micronuclei
TODO - The effect of the reportedly low ionizing radiation doses, such as those
very often delivered to patients in interventional cardiology, remains
ambiguous. As interventional cardiac procedures may have a significant
impact on total collective effective dose, there are radiation
protection concerns for patients and physicians regarding potential late
health effects. Given that very low doses (<100 mSv) are expected to be
delivered during these procedures, the purpose of this study was to
assess the potency and suitability of current genotoxicity biomarkers to
detect and quantitate biological effects essential for risk estimation
in interventional cardiology. Specifically, the biomarkers gamma-H2AX
foci, dicentric chromosomes, and micronuclei, which underpin
radiation-induced DNA damage, were studied in blood lymphocytes of 25
adult patients before and after interventional cardiac procedures. Even
though the mean values of all patients as a group for all three
endpoints tested show increased yields relative to baseline following
medical exposure, our results demonstrate that only the gamma-H2AX
biomarker enables detection of statistically significant differences at
the individual level (p < 0.001) for almost all patients (91%).
Furthermore, 24 h after exposure, residual gamma-H2AX foci were still
detectable in irradiated lymphocytes. Their decline was found to vary
significantly among the individuals and the repair kinetics of
gamma-H2AX foci was found to range from 25 to 95.6% of their maximum
values obtained.
ER -