TY - JOUR
TI - Lack of Association Between the ACE2 G8790A Gene Variation and Risk for
Basal Cell Carcinoma
AU - Gintoni, Iphigenia
AU - Vassiliou, Stavros
AU - Avgoustidis, Dimitris and
AU - Adamopoulou, Mary
AU - Zavras, Nikolaos
AU - Papakosta, Veronica and
AU - Vlachakis, Dimitris
AU - Yapijakis, Christos
JO - ANTICANCER RESEARCH
PY - 2021
VL - 41
TODO - 8
SP - 4021-4026
PB - INT INST ANTICANCER RESEARCH
SN - 0250-1291
TODO - 10.21873/anticanres.15201
TODO - Basal cell carcinoma; angiotensin-converting enzyme 2; angiotensin;
G8790A; rs2285666; DNA polymorphism; skin cancer
TODO - Background/Aim: The G8790A (rs2285666) functional polymorphism of the
angiotensin-converting enzyme 2 (ACE2) gene influences alternative mRNA
splicing and quantitatively affects the enzyme's production.
Specifically, the presence of the A allele has been associated with
higher ACE2 plasma levels. In this study, we investigated the possible
association of the functional polymorphism ACE2-G8790A with the
pathogenesis of basal cell carcinoma (BCC). Patients and Methods: A
total of 190 DNA samples were studied, including 91 BCC patients and 99
controls of Greek origin. Molecular genotyping for the ACE2 G8790A
polymorphism was carried out by PCR amplification, followed by AluI
enzyme digestion and agarose gel electrophoresis of the DNA fragments.
Results: The allelic and genotypic frequencies presented no statistical
difference between the patient and the control group. Conclusion: There
is no association between the ACE2 G8790A polymorphism and pathogenesis
of BCC.
ER -