TY - JOUR
TI - Introducing intrauterine antibiotic infusion as a novel approach in
effectively treating chronic endometritis and restoring reproductive
dynamics: a randomized pilot study
AU - Pantos, Konstantinos
AU - Simopoulou, Mara
AU - Maziotis, Evangelos and
AU - Rapani, Anna
AU - Grigoriadis, Sokratis
AU - Tsioulou, Petroula and
AU - Giannelou, Polina
AU - Nitsos, Nikolaos
AU - Tzonis, Panagiotis and
AU - Koutsilieris, Michael
AU - Sfakianoudis, Konstantinos
JO - Scientific Reports
PY - 2021
VL - 11
TODO - 1
SP - null
PB - NATURE PORTFOLIO
SN - 2045-2322
TODO - 10.1038/s41598-021-95072-w
TODO - null
TODO - The chronic nature of Chronic Endometritis (CE) along with the
challenging management and infertility entailed, call for cutting-edge
therapeutic approaches. This study introduces the novel treatment of
intrauterine antibiotic infusion (IAI) combined with oral antibiotic
administration (OAA), and it assesses respective performance against the
gold standard treatment of OAA. Data sourced herein reports on treatment
efficiency and fertility restoration for both patients aiming to
conceive naturally or via In Vitro fertilization. Eighty CE patients, 40
presenting with recurrent implantation failure, and 40 with recurrent
pregnancy loss, were enrolled in the IVF and the natural conception arm
respectively. Treatment was subjected to randomization. Effectively
treated patients proceeded with either a single IVF cycle or were
invited to conceive naturally over a 6-month period. Combination of IAI
and OAA provided a statistically significant enhanced effectiveness
treatment rate (RR 1.40; 95%CI 1.07-1.82; p=0.01). No statistically
significant difference was observed regarding the side-effects rate (RR
1.33; 95%CI 0.80-2.22; p=0.52). No statistically significant difference
was observed for either arm regarding live-birth rate. Following an
intention-to-treat analysis, employment of IAI corresponds to improved
clinical pregnancy rate-albeit not reaching statistical significance. In
conclusion, complimentary implementation of IAI could provide a
statistically significant enhanced clinical treatment outcome.
ER -