TY - JOUR
TI - Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields,
Cation Channels and Biological Effects
AU - Georgiou, Christos D.
AU - Margaritis, Lukas H.
JO - International Journal of Molecular Sciences
PY - 2021
VL - 22
TODO - 18
SP - null
PB - MDPI
SN - 1422-0067
TODO - 10.3390/ijms221810041
TODO - EMF; voltage-gated calcium channels; cation channels; ROS; DNA damage;
carcinogenesis
TODO - Electromagnetic fields (EMFs) disrupt the electrochemical balance of
biological membranes, thereby causing abnormal cation movement and
deterioration of the function of membrane voltage-gated ion channels.
These can trigger an increase of oxidative stress (OS) and the
impairment of all cellular functions, including DNA damage and
subsequent carcinogenesis. In this review we focus on the main
mechanisms of OS generation by EMF-sensitized NADPH oxidase (NOX), the
involved OS biochemistry, and the associated key biological effects.
ER -