TY - JOUR
TI - Updates and Ongoing Challenges in Imaging of Multiple Myeloma: AJR
Expert Panel Narrative Review
AU - Wu, Fangbai
AU - Bernard, Stephanie
AU - Fayad, Laura M.
AU - Ilaslan,
AU - Hakan
AU - Messiou, Christina
AU - Moulopoulos, Lia Angela
AU - Mulligan,
AU - Michael E.
JO - AJR.  AMERICAN JOURNAL OF ROENTGENOLOGY
PY - 2021
VL - 217
TODO - 4
SP - 775-785
PB - AMER ROENTGEN RAY SOC
SN - 0361-803X
TODO - 10.2214/AJR.21.25878
TODO - International Myeloma Working Group; multiple myeloma; PET/CT;
whole-body low-dose CT; whole-body MRI
TODO - Advances in the understanding and treatment of multiple myeloma have led
to the need for more sensitive and accurate imaging of intramedullary
and extramedullary disease. This role of imaging is underscored by
recently revised imaging recommendations of the International Myeloma
Working Group (IMWG). This narrative review discusses these
recommendations from the IMWG for different disease stages, focusing on
advanced whole-body modalities, and addresses related challenges and
controversies. In the recommendations, whole-body low-dose CT is central
in initial patient assessment, replacing the conventional skeletal
survey. Although the recommendations favor MRI for diagnosis because of
its superior sensitivity and utility in identifying myeloma-defining
events, FDG PET/CT is recommended as the modality of choice for
assessing treatment response. Consensus opinions are offered regarding
the role of imaging in multiple myeloma for characterization of disease
distribution, determination of prognosis, and response evaluation.
ER -