TY - JOUR
TI - Effects of hormone replacement therapy on endothelial function, arterial
stiffness and myocardial deformation in women with Turner syndrome
AU - Peppa, Melpomeni
AU - Pavlidis, George
AU - Mavroeidi, Ioanna and
AU - Katogiannis, Konstantinos
AU - Varoudi, Maria
AU - Thymis, John and
AU - Kostelli, Gavriella
AU - Vlastos, Dimitrios
AU - Plotas, Panagiotis and
AU - Bamias, Aristotelis
AU - Parissis, John
AU - Ikonomidis, Ignatios
JO - JOURNAL OF HYPERTENSION
PY - 2021
VL - 39
TODO - 10
SP - 2051-2057
PB - Lippincott, Williams & Wilkins
SN - -
TODO - 10.1097/HJH.0000000000002903
TODO - arterial stiffness; endothelial function; hormone replacement therapy;
myocardial deformation; Turner syndrome
TODO - Objectives: Turner syndrome (TS) is associated with increased
cardiovascular risk. We investigated whether hormone replacement therapy
(HRT) affects endothelial function, arterial stiffness and myocardial
deformation in women with TS. Methods: Twenty-five women with TS were
studied in the estrogen phase of the HRT and two months after
discontinuation of HRT. The following measurements were made:
flow-mediated dilation (FMD) of the brachial artery, pulse wave velocity
(PWV-Complior) and central systolic blood pressure (cSBP), carotid
intima-media thickness (cIMT), aortic (Ao) elastic indexes - namely Ao
strain, distensibility, stiffness index and pressure strain modulus
(E-p) - and left ventricular (LV) global longitudinal strain (GLS) using
speckle-tracking echocardiography. Ten healthy female of similar age and
BMI served as a control group. Results: Compared to controls, women with
TS on HRT had higher PWV (9.1 +/- 2.4 vs. 7.5 +/- 0.5 m/s), cSBP (130
+/- 15 vs. 121 +/- 6 mmHg), cIMT (0.66 +/- 0.06 vs. 0.55 +/- 0.05 mm),
aortic stiffness index, E-p and LA strain, and lower FMD (7.2 +/- 4 vs.
10.5 +/- 2.3%), Ao strain, Ao distensibility and GLS (-18.8 +/- 2.7 vs.
-21.9 +/- 1.5%) (P < 0.05 for all comparisons). Two months after
discontinuation of HRT, all women increased FMD (11.7 +/- 6 vs. 7.2 +/-
4%) and reduced PWV (7.8 +/- 1.7 vs. 9.1 +/- 2.4 m/s) and cSBP (123 +/-
14 vs. 130 +/- 15 mmHg). There were no statistically significant changes
in BMI, cIMT and GLS (P > 0.05 for all comparisons). The percentage
decrease of cSBP was associated with the percentage decrease of PWV (r =
0.54) and reversely related with the percentage increase of FMD (r =
-0.57; P < 0.05 for all comparisons). Conclusions: HRT in women with TS
may deteriorate endothelial function contributing to increased arterial
stiffness and central arterial blood pressure.
ER -