TY - JOUR
TI - Diagnostic Performance of Frequency-Domain Optical Coherence Tomography
to Predict Functionally Significant Left Main Coronary Artery Stenosis
AU - Bouki, Konstantina P.
AU - Vlad, I, Delia
AU - Goulas, Nikolaos and
AU - Lambadiari, Vaia A.
AU - Dimitriadis, George D.
AU - Kotsakis, Athanasios
AU - A.
AU - Baroutsi, Kyriaki
AU - Toutouzas, Konstantinos P.
JO - Journal of Interventional Cardiology
PY - 2021
VL - 2021
TODO - null
SP - null
PB - WILEY-HINDAWI
SN - 0896-4327, 1540-8183
TODO - 10.1155/2021/7108284
TODO - null
TODO - Aims. The aim of this study was to assess the safety and diagnostic
efficacy of frequency-domain optical coherence tomography (FD-OCT) in
identifying functional severity of the left main coronary artery (LM)
stenosis determined by fractional flow reserve (FFR). Methods and
Results. 101 patients with LM lesion (20-70% diameter stenosis
angiographically) underwent FFR measurement and FD-OCT imaging of the
LM. The following parameters were measured by FD-OCT in the LM:
reference lumen area (RLA), reference lumen diameter (RLD), minimum
lumen area (MLA), minimum lumen diameter (MLD), % lumen area stenosis,
and % diameter stenosis. The LM lesions were analyzable by FD-OCT in
88/101 (87.1%) patients. FFR at maximum hyperemia was <= 0.80 in 39/88
(44.3%) patients. FFR values were correlated significantly with
FD-OCT-derived LM lumen parameters. An MLA cutoff value of 5.38 mm(2)
had the highest sensitivity and specificity of 82% and 81%,
respectively, followed by an MLD of 2.43 mm (sensitivity 77%,
specificity 72%) and AS of 60% (sensitivity 72%, specificity 72%)
for predicting FFR Conclusions. FD-OCT is a safe and feasible imaging
technique for the assessment of LM stenosis. An FD-OCT-derived MLA of <=
5.38 mm(2) strongly predicts the functional severity of an LM lesion.
ER -