TY - JOUR
TI - Male Age and Progressive Sperm Motility Are Critical Factors Affecting
Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles
AU - Vogiatzi, Paraskevi
AU - Pouliakis, Abraham
AU - Sakellariou, Maria and
AU - Athanasiou, Aikaterini
AU - Athanasiou, Adamantios
AU - Colaghis,
AU - Alexandros
AU - Finelli, Renata
AU - Loutradis, Dimitrios
AU - Henkel, Ralf
AU - and Agarwal, Ashok
JO - Animal Reproduction Science
PY - 2022
VL - 29
TODO - 3
SP - 883-895
PB - Springer Berlin Heidelberg
SN - 0378-4320
TODO - 10.1007/s43032-021-00801-1
TODO - Male infertility; Paternal age; Semen analysis; Oocyte donation; IVF;
ICSI
TODO - This retrospective cohort study aimed to explore whether paternal age
and semen quality parameters affect the embryological and clinical
outcomes of ICSI with oocyte donation. A total of 339 oocyte donation
(OD)-ICSI cycles were categorized into four groups according to the
semen parameter profiles of the male counterparts: normozoospermia (NS,
n = 184), oligozoospermia (OS, n = 41), asthenozoospermia (AS, n = 50),
and oligoasthenozoospermia (OAS, n = 64). The effect of age, total sperm
count, and progressive motility was separately analyzed for reproductive
outcomes and compared between the study groups: fertilization,
blastulation, and top-quality embryo rate, biochemical and clinical
pregnancy, live birth, and miscarriage. A negative correlation between
male age and fertilization rate was observed (r(s) = - 0.23, p <
0.0001), while male age was a significant factor for biochemical
pregnancy (p = 0.0002), clinical pregnancy (p = 0.0017), and live birth
(p = 0.0038). Reduced total sperm count and lowered progressive motility
led to poorer fertilization rates (r(s) = 0.19 and 0.35, respectively, p
< 0.0001) and affected embryo quality (r(s) = 0.13, p = 0.02, and r(s) =
0.22, p < 0.0001, respectively). OD-ICSI cycles with asthenozoospermia
had significantly lowered success rates in biochemical pregnancy,
clinical pregnancy, and live birth (p < 0.05). Our study demonstrated
that both advanced male age and reduced progressive motility of
spermatozoa exert a significant negative influence on the outcome of
assisted reproduction, even in controlled procedures with gamete
selection and optimization such as in OD-ICSI. Improvement in treatment
strategies and male fertility evaluation requires incorporation of such
evidence to obtain better prognosis towards personalized management.
ER -