TY - JOUR
TI - Clinical and dermatoscopic predictors of squamous cell carcinoma of the
lips: a case-control, multicentric study
AU - Lallas, A.
AU - Martinez, G.
AU - Arceu, M.
AU - Kyrgidis, A.
AU - Liopyris,
AU - K.
AU - Brancaccio, G.
AU - Longo, C.
AU - Errichetti, E.
AU - Sgouros, D.
AU - and Papageorgiou, C.
AU - Fotiadou, C.
AU - Siskou, S.
AU - Manoli, S. M.
AU - and Sotiriou, E.
AU - Ioannides, D.
AU - Katoulis, A.
AU - Lazaridou, E.
AU - and Todorovska, V
AU - Argenziano, G.
AU - Apalla, Z.
JO - Journal of the European Academy of Dermatology and Venereology
PY - 2022
VL - 36
TODO - 2
SP - 222-227
PB - Wiley
SN - 0926-9959, 1468-3083
TODO - 10.1111/jdv.17790
TODO - actinic cheilitis; cheilitis; dermatoscopy; differential diagnosis;
lips; squamous cell carcinoma
TODO - Background Squamous cell carcinoma of the lip accounts for 20% of all
oral carcinomas. Its diagnosis may be challenging because it clinically
resembles actinic cheilitis and inflammatory lesions of the lips.
Objectives To determine clinical and dermatoscopic predictors of
squamous cell carcinoma of the lip vs. other lip lesions. Methods
Multicentre retrospective morphological study, including histologically
confirmed cases of squamous cell carcinoma of the lip and controls
consisting of actinic cheilitis and inflammatory lesions of the lips.
Clinical and dermatoscopic images were evaluated for the presence of
predefined criteria. Crude and adjusted odds ratios and corresponding
95% confidence intervals were calculated by univariate and multivariate
logistic regression respectively. Results A total of 177 lip lesions
were evaluated, 107 (60.5%) were squamous cell carcinomas and 70
(39.5%) were controls. The most frequent dermatoscopic criteria of lip
squamous cell carcinoma were scales (100%), white halos (87.3%) and
ulceration (79.4%). The majority of squamous cell carcinomas displayed
polymorphic vessels (60.8%), with linear (68.6%) and hairpin (67.6%)
being the most frequent types. Multivariate logistic regression analysis
showed that clinical predictors of lip squamous cell carcinoma were
exophytic appearance and clinical hyperkeratosis, with 43-fold and
6-fold higher probability respectively. White clods and ulceration in
dermoscopy presented a 6-fold and 4-fold increased risk for squamous
cell carcinoma respectively. Conclusions A scaly lesion with exophytic
growth, dermatoscopically displaying white clods, ulceration and linear
and hairpin vessels is very likely a squamous cell carcinoma of the lip.
ER -