TY - JOUR
TI - Pathophysiology of Circulating Biomarkers and Relationship With Vascular
Aging: A Review of the Literature From VascAgeNet Group on Circulating
Biomarkers, European Cooperation in Science and Technology Action 18216
AU - Gopcevic, Kristina R.
AU - Gkaliagkousi, Eugenia
AU - Nemcsik, Janos and
AU - Acet, Omur
AU - Bernal-Lopez, M. Rosa
AU - Bruno, Rosa M.
AU - Climie,
AU - Rachel E.
AU - Fountoulakis, Nikolaos
AU - Fraenkel, Emil
AU - Lazaridis,
AU - Antonios
AU - Navickas, Petras
AU - Rochfort, Keith D.
AU - Satrauskiene,
AU - Agne
AU - Zupkauskiene, Jurate
AU - Terentes-Printzios, Dimitrios
JO - FRONTIERS IN PHYSIOLOGY
PY - 2021
VL - 12
TODO - null
SP - null
PB - Frontiers Media SA
SN - null
TODO - 10.3389/fphys.2021.789690
TODO - vascular aging; circulating biomarkers; oxidative stress; inflammation;
cellular matrix; epigenetics
TODO - Impairment of the arteries is a product of sustained exposure to various
deleterious factors and progresses with time; a phenomenon inherent to
vascular aging. Oxidative stress, inflammation, the accumulation of
harmful agents in high cardiovascular risk conditions, changes to the
extracellular matrix, and/or alterations of the epigenetic modification
of molecules, are all vital pathophysiological processes proven to
contribute to vascular aging, and also lead to changes in levels of
associated circulating molecules. Many of these molecules are
consequently recognized as markers of vascular impairment and
accelerated vascular aging in clinical and research settings, however,
for these molecules to be classified as biomarkers of vascular aging,
further criteria must be met. In this paper, we conducted a scoping
literature review identifying thirty of the most important, and eight
less important, biomarkers of vascular aging. Herein, we overview a
selection of the most important molecules connected with the
above-mentioned pathological conditions and study their usefulness as
circulating biomarkers of vascular aging.
ER -