TY - JOUR
TI - Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek
Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body
Mass Index
AU - Garoufi, Anastasia
AU - Pagoni, Athanasia
AU - Papadaki, Maria and
AU - Marmarinos, Antonios
AU - Karapostolakis, Georgios
AU - Michala, Lina and
AU - Soldatou, Alexandra
JO - CHILDREN-BASEL
PY - 2022
VL - 9
TODO - 1
SP - null
PB - MDPI
SN - null
TODO - 10.3390/children9010004
TODO - abdominal obesity; insulin resistance; lipid profile; small dense
low-density lipoprotein cholesterol; visceral adiposity index; lipid
accumulation product; carotid intima-media thickness; non-alcoholic
fatty liver disease
TODO - Polycystic ovary syndrome (PCOS) is the most common endocrine condition
affecting 6-18% of adolescents and is strongly associated with obesity
and cardiovascular risk factors, enhancing the risk of atherosclerosis.
Thirty-two adolescents with newly diagnosed PCOS were evaluated for
lipid profile disorders, insulin resistance, inflammation, non-alcoholic
fatty liver disease (NAFLD), and subclinical atherosclerosis through
measurements of carotid intima-media thickness (cIMT). The relationships
of the above markers with increased body mass index and abdominal
obesity were investigated. Twenty-three adolescents (72%) were
overweight (OW) or obese (OB). The OW/OB group had significantly higher
insulin, HOMA-IR, high-sensitive C-reactive protein (hsCRP), visceral
adiposity index (VAI), and lipid accumulation product (LAP) levels; and
lower glucose-per-insulin ratios and HDL-C levels compared to the
healthy weight group. The cIMT and small dense low-density lipoprotein
cholesterol (sdLDL-C) levels did not differ between the two groups.
Similarly, cIMT and sdLDL-C levels did not differ between
PCOS-adolescents and healthy controls. CIMT was positively correlated
with systolic blood pressure and waist circumference per height ratio.
In conclusion, OW/OB PCOS-adolescents have a cluster of adverse factors
predisposing them to atherosclerotic cardiovascular disease. Therefore,
early cardiovascular risk assessment, as well as timely and targeted
interventions, are necessary for prevention.
ER -