TY - JOUR
TI - Coffee consumption and gastric cancer: a pooled analysis from the
Stomach cancer Pooling Project consortium
AU - Martimianaki, Georgia
AU - Bertuccio, Paola
AU - Alicandro, Gianfranco and
AU - Pelucchi, Claudio
AU - Bravi, Francesca
AU - Carioli, Greta
AU - Bonzi,
AU - Rossella
AU - Rabkin, Charles S.
AU - Liao, Linda M.
AU - Sinha, Rashmi and
AU - Johnson, Ken
AU - Hu, Jinfu
AU - Palli, Domenico
AU - Ferraroni, Monica and
AU - Lunet, Nuno
AU - Morais, Samantha
AU - Tsugane, Shoichiro
AU - Hidaka,
AU - Akihisa
AU - Hamada, Gerson Shigueaki
AU - Lopez-Carrillo, Lizbeth and
AU - Hernandez-Ramirez, Raul Ulises
AU - Zaridze, David
AU - Maximovitch,
AU - Dmitry
AU - Aragones, Nuria
AU - Martin, Vicente
AU - Ward, Mary H. and
AU - Vioque, Jesus
AU - Garcia de la Hera, Manoli
AU - Zhang, Zuo-Feng and
AU - Kurtz, Robert C.
AU - Lagiou, Pagona
AU - Lagiou, Areti
AU - Trichopoulou,
AU - Antonia
AU - Karakatsani, Anna
AU - Malekzadeh, Reza
AU - Camargo, M.
AU - Constanza
AU - Curado, Maria Paula
AU - Boccia, Stefania
AU - Boffetta,
AU - Paolo
AU - Negri, Eva
AU - La Vecchia, Carlo
JO - European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP)
PY - 2022
VL - 31
TODO - 2
SP - 117-127
PB - Lippincott, Williams & Wilkins
SN - 0959-8278
TODO - 10.1097/CEJ.0000000000000680
TODO - cardia cancer; case-control study; coffee; gastric cancer; pooled
analysis
TODO - Objective This study aimed to evaluate and quantify the relationship
between coffee and gastric cancer using a uniquely large dataset from an
international consortium of observational studies on gastric cancer,
including data from 18 studies, for a total of 8198 cases and 21 419
controls. Methods A two-stage approach was used to obtain the pooled
odds ratios (ORs) and the corresponding 95% confidence intervals (CIs)
for coffee drinkers versus never or rare drinkers. A one-stage logistic
mixed-effects model with a random intercept for each study was used to
estimate the dose-response relationship. Estimates were adjusted for
sex, age and the main recognized risk factors for gastric cancer.
Results Compared to never or rare coffee drinkers, the estimated pooled
OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of
coffee intake was considered, the pooled ORs were 0.91 (95% CI,
0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10)
for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR
of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven
or more cups of caffeinated coffee per day). A positive association
emerged for high coffee intake (five or more cups per day) for gastric
cardia cancer only. Conclusions These findings better quantify the
previously available evidence of the absence of a relevant association
between coffee consumption and gastric cancer.
ER -